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A coumarin analogue NFA from endophytic Aspergillus fumigatus improves drought resistance in rice as an antioxidant.
Qin, Wanggege; Liu, Chengxiong; Jiang, Wei; Xue, Yanhong; Wang, Guangxi; Liu, Shiping.
Afiliación
  • Qin W; College of Life Science and Pharmacy, China Three Gorges University, Yichang, 443002, China.
  • Liu C; College of Life Science and Pharmacy, China Three Gorges University, Yichang, 443002, China.
  • Jiang W; Hubei Key Laboratory of Natural Products Research and Development, College of Life Science and Pharmacy, China Three Gorges University, Yichang, 443002, China.
  • Xue Y; College of Life Science and Pharmacy, China Three Gorges University, Yichang, 443002, China.
  • Wang G; Laboratory of Plant Conservation Science, Faculty of Agriculture, Meijo University, Aichi, 468-8502, Japan.
  • Liu S; College of Life Science and Pharmacy, China Three Gorges University, Yichang, 443002, China.
BMC Microbiol ; 19(1): 50, 2019 02 26.
Article en En | MEDLINE | ID: mdl-30808281
ABSTRACT

BACKGROUND:

Drought and its resulting oxidative damage are the major yield limiting factors for crops in arid and semi-arid regions. Recent studies have found that endophytic fungi coexisting in plants can alleviate biotic or abiotic damage to plant growth and development. In order to screen for the endophytes associated with drought stress, 12 strains of endophytic fungi with high antioxidant activity isolated from riparian plants Myricaria laxiflora were evaluated for their effects in rice by the crude extracts.

RESULTS:

Of the 12 endophytic fungi, Aspergillus fumigatus SG-17 functioned most effectively, with the crude extract exhibiting relatively higher antioxidant capacity both in vivo and in vitro. The subsequent MS and NMR analysis showed that the primary substance responsible for the antioxidant activity in the extract was (Z)-N-(4-hydroxystyryl) formamide (NFA), an analogue of coumarin. Enzyme activity assay in nerve cells SH-SY5Y showed that NFA could maintain the membrane integrity and regulate the antioxidase activity under oxidative stress. In rice suffering drought stress, NFA effectively alleviated the harm by regulating the contents of NADPH oxidases, antioxidants and heat shock proteins, all of which are closely related with the reactive oxygen species pathway.

CONCLUSION:

These findings indicated that some endophytes from plants often subjected to flooding and oxidative stress could enhance drought resistance by producing compounds such as NFA to regulate the oxidative pathway.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Aspergillus fumigatus / Oryza / Sequías / Formamidas / Antioxidantes Idioma: En Revista: BMC Microbiol Asunto de la revista: MICROBIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Aspergillus fumigatus / Oryza / Sequías / Formamidas / Antioxidantes Idioma: En Revista: BMC Microbiol Asunto de la revista: MICROBIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: China