A mutually induced conformational fit underlies Ca<sup>2+</sup>-directed interactions between calmodulin and the proximal C terminus of KCNQ4 K<sup>+</sup> channels.

Archer, Crystal R; Enslow, Benjamin T; Taylor, Alexander B; De la Rosa, Victor; Bhattacharya, Akash; Shapiro, Mark S

A mutually induced conformational fit underlies Ca²⁺-directed interactions between calmodulin and the proximal C terminus of KCNQ4 K⁺ channels.

Archer, Crystal R; Enslow, Benjamin T; Taylor, Alexander B; De la Rosa, Victor; Bhattacharya, Akash; Shapiro, Mark S.

Afiliación

Archer CR; From the Departments of Cell and Integrative Physiology, University of Texas Health San Antonio, San Antonio, Texas 78229; Departments of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, Texas 78229.
Enslow BT; the Long School of Medicine, University of Texas Health San Antonio, San Antonio, Texas 78229.
Taylor AB; Departments of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, Texas 78229.
De la Rosa V; From the Departments of Cell and Integrative Physiology, University of Texas Health San Antonio, San Antonio, Texas 78229.
Bhattacharya A; Departments of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, Texas 78229.
Shapiro MS; From the Departments of Cell and Integrative Physiology, University of Texas Health San Antonio, San Antonio, Texas 78229. Electronic address: shapirom@uthscsa.edu.

J Biol Chem ; 294(15): 6094-6112, 2019 04 12.

Article en En | MEDLINE | ID: mdl-30808708

Asunto(s)

Calcio/química; Calmodulina/química; Canales de Potasio KCNQ/química; Animales; Células CHO; Calcio/metabolismo; Calmodulina/genética; Calmodulina/metabolismo; Cricetulus; Cristalografía por Rayos X; Humanos; Activación del Canal Iónico; Canales de Potasio KCNQ/genética; Canales de Potasio KCNQ/metabolismo; Dominios Proteicos; Estructura Secundaria de Proteína

Palabras clave

M current; X-ray crystallography; biophysical chemical analysis; calcium signaling; calcium-binding protein; calmodulin (CaM); conformational change; isothermal titration calorimetry (ITC); microscale thermophoresis (MST); nuclear magnetic resonance (NMR); potassium channel; potassium voltage-gated channel subfamily Q member (KCNQ)

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Calmodulina / Calcio / Canales de Potasio KCNQ Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Biol Chem Año: 2019 Tipo del documento: Article

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