Increase in the nuclear localization of PTEN by the Toxoplasma GRA16 protein and subsequent induction of p53-dependent apoptosis and anticancer effect.

Kim, Sang-Gyun; Seo, Seung-Hwan; Shin, Ji-Hun; Yang, Jung-Pyo; Lee, Sang Hyung; Shin, Eun-Hee

Kim, Sang-Gyun; Seo, Seung-Hwan; Shin, Ji-Hun; Yang, Jung-Pyo; Lee, Sang Hyung; Shin, Eun-Hee.

Afiliación

Kim SG; Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine and Institute of Endemic Diseases, Seoul, Republic of Korea.
Seo SH; Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine and Institute of Endemic Diseases, Seoul, Republic of Korea.
Shin JH; Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine and Institute of Endemic Diseases, Seoul, Republic of Korea.
Yang JP; Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine and Institute of Endemic Diseases, Seoul, Republic of Korea.
Lee SH; Department of Neurosurgery, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea.
Shin EH; Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine and Institute of Endemic Diseases, Seoul, Republic of Korea.

J Cell Mol Med ; 23(5): 3234-3245, 2019 05.

Article en En | MEDLINE | ID: mdl-30834688

Asunto(s)

Carcinoma Hepatocelular/terapia; Neoplasias Hepáticas/terapia; Proteínas Protozoarias/genética; Proteína p53 Supresora de Tumor/genética; Peptidasa Específica de Ubiquitina 7/genética; Animales; Apoptosis/genética; Carcinogénesis/genética; Carcinoma Hepatocelular/genética; Carcinoma Hepatocelular/patología; Movimiento Celular/genética; Proliferación Celular/genética; Células Hep G2; Xenoinjertos; Humanos; Hígado/metabolismo; Hígado/patología; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/patología; Ratones; Fosfohidrolasa PTEN/genética; Unión Proteica/genética; Proteínas Protozoarias/metabolismo; Toxoplasma/genética; Peptidasa Específica de Ubiquitina 7/antagonistas & inhibidores

Palabras clave

GRA16-stable cell line; HAUSP; Hep3B; HepG2; PTEN; Toxoplasma GRA16; USP7; cell cycle arrest; hepatocellular carcinoma; p53

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Protozoarias / Proteína p53 Supresora de Tumor / Carcinoma Hepatocelular / Peptidasa Específica de Ubiquitina 7 / Neoplasias Hepáticas Límite: Animals / Humans Idioma: En Revista: J Cell Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2019 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google