Nuclear Magnetic Resonance Spectroscopy to Identify Metabolite Biomarkers of Nonresponsiveness to Targeted Therapy in Glioblastoma Tumor Stem Cells.

Hvinden, Ingvild Comfort; Berg, Henriette Engen; Sachse, Daniel; Skaga, Erlend; Skottvoll, Frøydis Sved; Lundanes, Elsa; Sandberg, Cecilie J; Vik-Mo, Einar O; Rise, Frode; Wilson, Steven Ray

Hvinden, Ingvild Comfort; Berg, Henriette Engen; Sachse, Daniel; Skaga, Erlend; Skottvoll, Frøydis Sved; Lundanes, Elsa; Sandberg, Cecilie J; Vik-Mo, Einar O; Rise, Frode; Wilson, Steven Ray.

Afiliación

Hvinden IC; Department of Chemistry , University of Oslo , Post Box 1033, Blindern NO-0315 , Oslo , Norway.
Berg HE; Department of Chemistry , Chemistry Research Laboratory, University of Oxford , 12 Mansfield Road , Oxford OX1 3TA , United Kingdom.
Sachse D; Department of Chemistry , University of Oslo , Post Box 1033, Blindern NO-0315 , Oslo , Norway.
Skaga E; Department of Chemistry , University of Oslo , Post Box 1033, Blindern NO-0315 , Oslo , Norway.
Skottvoll FS; Vilhelm Magnus Laboratory of Neurosurgical Research, Institute for Surgical Research and Department of Neurosurgery , Oslo University Hospital , 4950 Nydalen NO-0424 , Oslo , Norway.
Lundanes E; Institute of Clinical Medicine, Faculty of Medicine , University of Oslo , Post Box 1171, Blindern NO-0318 , Oslo , Norway.
Sandberg CJ; Department of Chemistry , University of Oslo , Post Box 1033, Blindern NO-0315 , Oslo , Norway.
Vik-Mo EO; Hybrid Technology Hub, Centre of Excellence, Institute of Basic Medical Sciences, Faculty of Medicine , University of Oslo , PO Box 1112, Blindern NO-0317 , Oslo , Norway.
Rise F; Department of Chemistry , University of Oslo , Post Box 1033, Blindern NO-0315 , Oslo , Norway.
Wilson SR; Vilhelm Magnus Laboratory of Neurosurgical Research, Institute for Surgical Research and Department of Neurosurgery , Oslo University Hospital , 4950 Nydalen NO-0424 , Oslo , Norway.

J Proteome Res ; 18(5): 2012-2020, 2019 05 03.

Article en En | MEDLINE | ID: mdl-30964684

Asunto(s)

Antineoplásicos/uso terapéutico; Neoplasias Encefálicas/tratamiento farmacológico; Ácido Cítrico/metabolismo; Glioblastoma/tratamiento farmacológico; Imidazoles/uso terapéutico; Ácido Láctico/metabolismo; Metaboloma; Naftoquinonas/uso terapéutico; Biomarcadores Farmacológicos/metabolismo; Neoplasias Encefálicas/genética; Neoplasias Encefálicas/metabolismo; Neoplasias Encefálicas/patología; Supervivencia Celular/efectos de los fármacos; Ciclo del Ácido Cítrico/efectos de los fármacos; Ciclo del Ácido Cítrico/genética; Glioblastoma/genética; Glioblastoma/metabolismo; Glioblastoma/patología; Humanos; Espectroscopía de Resonancia Magnética; Terapia Molecular Dirigida/métodos; Células Madre Neoplásicas/efectos de los fármacos; Células Madre Neoplásicas/metabolismo; Células Madre Neoplásicas/patología; Cultivo Primario de Células; Análisis de Componente Principal; Survivin/antagonistas & inhibidores; Survivin/genética; Survivin/metabolismo

Palabras clave

NMR; cancer; glioblastoma; metabolomics; proteomics

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Naftoquinonas / Glioblastoma / Ácido Cítrico / Ácido Láctico / Metaboloma / Imidazoles / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Proteome Res Asunto de la revista: BIOQUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Noruega

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