Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase.

Kovarik, Zrinka; Macek Hrvat, Nikolina; Kalisiak, Jaroslaw; Katalinic, Maja; Sit, Rakesh K; Zorbaz, Tamara; Radic, Zoran; Fokin, Valery V; Sharpless, K Barry; Taylor, Palmer

Kovarik, Zrinka; Macek Hrvat, Nikolina; Kalisiak, Jaroslaw; Katalinic, Maja; Sit, Rakesh K; Zorbaz, Tamara; Radic, Zoran; Fokin, Valery V; Sharpless, K Barry; Taylor, Palmer.

Afiliación

Kovarik Z; Institute for Medical Research and Occupational Health, Zagreb, Croatia. Electronic address: zkovarik@imi.hr.
Macek Hrvat N; Institute for Medical Research and Occupational Health, Zagreb, Croatia.
Kalisiak J; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, USA.
Katalinic M; Institute for Medical Research and Occupational Health, Zagreb, Croatia.
Sit RK; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, USA.
Zorbaz T; Institute for Medical Research and Occupational Health, Zagreb, Croatia.
Radic Z; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, USA.
Fokin VV; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, USA.
Sharpless KB; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, USA.
Taylor P; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, USA. Electronic address: pwtaylor@ucsd.edu.

Toxicol Appl Pharmacol ; 372: 40-46, 2019 06 01.

Article en En | MEDLINE | ID: mdl-30978400

Asunto(s)

Antídotos/farmacología; Butirilcolinesterasa/metabolismo; Inhibidores de la Colinesterasa/toxicidad; Reactivadores de la Colinesterasa/farmacología; Organofosfatos/toxicidad; Oximas/farmacología; Acetilcolinesterasa/química; Acetilcolinesterasa/metabolismo; Antídotos/química; Butirilcolinesterasa/sangre; Butirilcolinesterasa/química; Dominio Catalítico; Reactivadores de la Colinesterasa/química; Femenino; Proteínas Ligadas a GPI/antagonistas & inhibidores; Proteínas Ligadas a GPI/química; Proteínas Ligadas a GPI/metabolismo; Humanos; Mutación; Oximas/química; Conformación Proteica; Proteínas Recombinantes/metabolismo; Relación Estructura-Actividad

Palabras clave

2PAM; Acetylcholinesterase reactivation; Antidotes to nerve agents; Bioscavengers; Organophosphates; Phosphoramidates

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oximas / Organofosfatos / Butirilcolinesterasa / Inhibidores de la Colinesterasa / Reactivadores de la Colinesterasa / Antídotos Límite: Female / Humans Idioma: En Revista: Toxicol Appl Pharmacol Año: 2019 Tipo del documento: Article

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