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Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway.
Karki, Rajeshri G; Powers, James; Mainolfi, Nello; Anderson, Karen; Belanger, David B; Liu, Donglei; Ji, Nan; Jendza, Keith; Gelin, Christine F; Mac Sweeney, Aengus; Solovay, Catherine; Delgado, Omar; Crowley, Maura; Liao, Sha-Mei; Argikar, Upendra A; Flohr, Stefanie; La Bonte, Laura R; Lorthiois, Edwige L; Vulpetti, Anna; Brown, Ann; Long, Debby; Prentiss, Melissa; Gradoux, Nathalie; de Erkenez, Andrea; Cumin, Frederic; Adams, Christopher; Jaffee, Bruce; Mogi, Muneto.
Afiliación
  • Karki RG; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States.
  • Powers J; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States.
  • Mainolfi N; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States.
  • Anderson K; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States.
  • Belanger DB; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States.
  • Liu D; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States.
  • Ji N; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States.
  • Jendza K; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States.
  • Gelin CF; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States.
  • Mac Sweeney A; Novartis Institutes for BioMedical Research , Novartis Campus , CH-4056 Basel , Switzerland.
  • Solovay C; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States.
  • Delgado O; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States.
  • Crowley M; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States.
  • Liao SM; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States.
  • Argikar UA; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States.
  • Flohr S; Novartis Institutes for BioMedical Research , Novartis Campus , CH-4056 Basel , Switzerland.
  • La Bonte LR; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States.
  • Lorthiois EL; Novartis Institutes for BioMedical Research , Novartis Campus , CH-4056 Basel , Switzerland.
  • Vulpetti A; Novartis Institutes for BioMedical Research , Novartis Campus , CH-4056 Basel , Switzerland.
  • Brown A; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States.
  • Long D; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States.
  • Prentiss M; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States.
  • Gradoux N; Novartis Institutes for BioMedical Research , Novartis Campus , CH-4056 Basel , Switzerland.
  • de Erkenez A; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States.
  • Cumin F; Novartis Institutes for BioMedical Research , Novartis Campus , CH-4056 Basel , Switzerland.
  • Adams C; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States.
  • Jaffee B; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States.
  • Mogi M; Novartis Institutes for BioMedical Research , Cambridge , Massachusetts 02139 , United States.
J Med Chem ; 62(9): 4656-4668, 2019 05 09.
Article en En | MEDLINE | ID: mdl-30995036
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Bencilaminas / Inhibidores de Serina Proteinasa / Vía Alternativa del Complemento Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Bencilaminas / Inhibidores de Serina Proteinasa / Vía Alternativa del Complemento Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos