TCR activation mimics CD127<sup>low</sup>PD-1<sup>high</sup> phenotype and functional alterations of T lymphocytes from septic shock patients.

Mouillaux, Julie; Allam, Camille; Gossez, Morgane; Uberti, Thomas; Delwarde, Benjamin; Hayman, Jack; Rimmelé, Thomas; Textoris, Julien; Monneret, Guillaume; Peronnet, Estelle; Venet, Fabienne

TCR activation mimics CD127^lowPD-1^high phenotype and functional alterations of T lymphocytes from septic shock patients.

Mouillaux, Julie; Allam, Camille; Gossez, Morgane; Uberti, Thomas; Delwarde, Benjamin; Hayman, Jack; Rimmelé, Thomas; Textoris, Julien; Monneret, Guillaume; Peronnet, Estelle; Venet, Fabienne.

Afiliación

Mouillaux J; EA 7426 « Pathophysiology of injury-induced immunosuppression (PI3) ¼ Lyon 1 University / Hospices Civils de Lyon / bioMérieux, Hôpital Edouard Herriot 5 place d'Arsonval, 69003, Lyon, France.
Allam C; Joint Research Unit HCL-bioMérieux-Université Lyon 1, Hôpital Edouard Herriot, 5 place d'Arsonval, 69003, Lyon, France.
Gossez M; EA 7426 « Pathophysiology of injury-induced immunosuppression (PI3) ¼ Lyon 1 University / Hospices Civils de Lyon / bioMérieux, Hôpital Edouard Herriot 5 place d'Arsonval, 69003, Lyon, France.
Uberti T; Immunology Laboratory, Hospices Civils de Lyon, Hôpital Edouard Herriot, 5 place d'Arsonval, 69003, Lyon, France.
Delwarde B; EA 7426 « Pathophysiology of injury-induced immunosuppression (PI3) ¼ Lyon 1 University / Hospices Civils de Lyon / bioMérieux, Hôpital Edouard Herriot 5 place d'Arsonval, 69003, Lyon, France.
Hayman J; Immunology Laboratory, Hospices Civils de Lyon, Hôpital Edouard Herriot, 5 place d'Arsonval, 69003, Lyon, France.
Rimmelé T; Anesthesiology and Intensive care department, Hospices Civils de Lyon, Hôpital Edouard Herriot 5 place d'Arsonval, 69003, Lyon, France.
Textoris J; Anesthesiology and Intensive care department, Hospices Civils de Lyon, Hôpital Edouard Herriot 5 place d'Arsonval, 69003, Lyon, France.
Monneret G; EA 7426 « Pathophysiology of injury-induced immunosuppression (PI3) ¼ Lyon 1 University / Hospices Civils de Lyon / bioMérieux, Hôpital Edouard Herriot 5 place d'Arsonval, 69003, Lyon, France.
Peronnet E; Immunology Laboratory, Hospices Civils de Lyon, Hôpital Edouard Herriot, 5 place d'Arsonval, 69003, Lyon, France.
Venet F; EA 7426 « Pathophysiology of injury-induced immunosuppression (PI3) ¼ Lyon 1 University / Hospices Civils de Lyon / bioMérieux, Hôpital Edouard Herriot 5 place d'Arsonval, 69003, Lyon, France.

Crit Care ; 23(1): 131, 2019 Apr 17.

Article en En | MEDLINE | ID: mdl-30995946

Asunto(s)

Choque Séptico/sangre; Linfocitos T/fisiología; Anciano; Femenino; Francia; Humanos; Interleucina-7/análisis; Interleucina-7/sangre; Interleucina-7/fisiología; Subunidad alfa del Receptor de Interleucina-7/análisis; Subunidad alfa del Receptor de Interleucina-7/sangre; Recuento de Linfocitos/métodos; Masculino; Persona de Mediana Edad; Fenotipo; Receptor de Muerte Celular Programada 1/análisis; Receptor de Muerte Celular Programada 1/sangre; Choque Séptico/fisiopatología

Palabras clave

CD127; Exhaustion; IL-7; Immunosuppression; PD-1; Sepsis; T-cell activation

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Choque Séptico / Linfocitos T Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Crit Care Año: 2019 Tipo del documento: Article País de afiliación: Francia

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