Phorbol ester causes short term and transient accumulation of pteridines in T cells and in cell lines.
Biochem Biophys Res Commun
; 141(2): 494-501, 1986 Dec 15.
Article
en En
| MEDLINE
| ID: mdl-3099788
ABSTRACT
Upon exposure to 12-O-tetradecanoylphorbol 13-acetate, interleukin 2 receptor+ T cells transiently accumulate neopterin and biopterin as was determined by HPLC after iodine oxidation of acidic cell extracts. Pteridines peak at maximally 20 fold levels after 10-20 min and return to initial levels during the following 30-40 min. Resting human peripheral blood mononuclear cells do not react within this short period. TPA elicits similar neopterin and biopterin accumulation kinetics in cell lines such as HL-60, Reh, Jurkat JMN, HeLa and 293, whereby HL-60 and Reh release substantial amounts of these transiently formed pteridines into the medium.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Pteridinas
/
Acetato de Tetradecanoilforbol
/
Linfocitos T
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Revista:
Biochem Biophys Res Commun
Año:
1986
Tipo del documento:
Article