Your browser doesn't support javascript.
loading
The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aß Plaques.
Sala Frigerio, Carlo; Wolfs, Leen; Fattorelli, Nicola; Thrupp, Nicola; Voytyuk, Iryna; Schmidt, Inga; Mancuso, Renzo; Chen, Wei-Ting; Woodbury, Maya E; Srivastava, Gyan; Möller, Thomas; Hudry, Eloise; Das, Sudeshna; Saido, Takaomi; Karran, Eric; Hyman, Bradley; Perry, V Hugh; Fiers, Mark; De Strooper, Bart.
Afiliación
  • Sala Frigerio C; VIB Centre for Brain Disease Research, Leuven, Belgium; University of Leuven, Department of Neurosciences and Leuven Brain Institute, Leuven, Belgium; UK Dementia Research Institute, University College London, London, UK. Electronic address: carlo.salafrigerio@kuleuven.vib.be.
  • Wolfs L; VIB Centre for Brain Disease Research, Leuven, Belgium; University of Leuven, Department of Neurosciences and Leuven Brain Institute, Leuven, Belgium.
  • Fattorelli N; VIB Centre for Brain Disease Research, Leuven, Belgium; University of Leuven, Department of Neurosciences and Leuven Brain Institute, Leuven, Belgium.
  • Thrupp N; VIB Centre for Brain Disease Research, Leuven, Belgium; University of Leuven, Department of Neurosciences and Leuven Brain Institute, Leuven, Belgium.
  • Voytyuk I; VIB Centre for Brain Disease Research, Leuven, Belgium; University of Leuven, Department of Neurosciences and Leuven Brain Institute, Leuven, Belgium.
  • Schmidt I; VIB Centre for Brain Disease Research, Leuven, Belgium; University of Leuven, Department of Neurosciences and Leuven Brain Institute, Leuven, Belgium.
  • Mancuso R; VIB Centre for Brain Disease Research, Leuven, Belgium; University of Leuven, Department of Neurosciences and Leuven Brain Institute, Leuven, Belgium.
  • Chen WT; VIB Centre for Brain Disease Research, Leuven, Belgium; University of Leuven, Department of Neurosciences and Leuven Brain Institute, Leuven, Belgium.
  • Woodbury ME; Foundational Neuroscience Center, AbbVie, Inc., Cambridge, MA, USA.
  • Srivastava G; Foundational Neuroscience Center, AbbVie, Inc., Cambridge, MA, USA.
  • Möller T; Foundational Neuroscience Center, AbbVie, Inc., Cambridge, MA, USA.
  • Hudry E; Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
  • Das S; Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
  • Saido T; Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako-shi, Saitama, Japan.
  • Karran E; Foundational Neuroscience Center, AbbVie, Inc., Cambridge, MA, USA.
  • Hyman B; Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
  • Perry VH; UK Dementia Research Institute, University College London, London, UK; Centre for Biological Sciences, University of Southampton, Southampton, UK.
  • Fiers M; VIB Centre for Brain Disease Research, Leuven, Belgium; University of Leuven, Department of Neurosciences and Leuven Brain Institute, Leuven, Belgium.
  • De Strooper B; VIB Centre for Brain Disease Research, Leuven, Belgium; University of Leuven, Department of Neurosciences and Leuven Brain Institute, Leuven, Belgium; UK Dementia Research Institute, University College London, London, UK. Electronic address: bart.destrooper@kuleuven.vib.be.
Cell Rep ; 27(4): 1293-1306.e6, 2019 04 23.
Article en En | MEDLINE | ID: mdl-31018141
ABSTRACT
Gene expression profiles of more than 10,000 individual microglial cells isolated from cortex and hippocampus of male and female AppNL-G-F mice over time demonstrate that progressive amyloid-ß accumulation accelerates two main activated microglia states that are also present during normal aging. Activated response microglia (ARMs) are composed of specialized subgroups overexpressing MHC type II and putative tissue repair genes (Dkk2, Gpnmb, and Spp1) and are strongly enriched with Alzheimer's disease (AD) risk genes. Microglia from female mice progress faster in this activation trajectory. Similar activated states are also found in a second AD model and in human brain. Apoe, the major genetic risk factor for AD, regulates the ARMs but not the interferon response microglia (IRMs). Thus, the ARMs response is the converging point for aging, sex, and genetic AD risk factors.
Asunto(s)
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Encéfalo / Envejecimiento / Biomarcadores / Microglía / Placa Amiloide / Modelos Animales de Enfermedad / Enfermedad de Alzheimer Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Cell Rep Año: 2019 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Encéfalo / Envejecimiento / Biomarcadores / Microglía / Placa Amiloide / Modelos Animales de Enfermedad / Enfermedad de Alzheimer Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Cell Rep Año: 2019 Tipo del documento: Article