Design, synthesis, and anticancer evaluation of novel quinoline derivatives of ursolic acid with hydrazide, oxadiazole, and thiadiazole moieties as potent MEK inhibitors.

Jin, Xiao-Yan; Chen, Hao; Li, Dong-Dong; Li, A-Liang; Wang, Wen-Yan; Gu, Wen

Jin, Xiao-Yan; Chen, Hao; Li, Dong-Dong; Li, A-Liang; Wang, Wen-Yan; Gu, Wen.

Afiliación

Jin XY; a Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-forest Biomass, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, Co-Innovation Center for Efficient Processing and Utilization of Forest Products, College of Chemical Engineering , Nanjing Forestry University , Nanjing
Chen H; a Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-forest Biomass, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, Co-Innovation Center for Efficient Processing and Utilization of Forest Products, College of Chemical Engineering , Nanjing Forestry University , Nanjing
Li DD; a Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-forest Biomass, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, Co-Innovation Center for Efficient Processing and Utilization of Forest Products, College of Chemical Engineering , Nanjing Forestry University , Nanjing
Li AL; a Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-forest Biomass, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, Co-Innovation Center for Efficient Processing and Utilization of Forest Products, College of Chemical Engineering , Nanjing Forestry University , Nanjing
Wang WY; a Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-forest Biomass, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, Co-Innovation Center for Efficient Processing and Utilization of Forest Products, College of Chemical Engineering , Nanjing Forestry University , Nanjing
Gu W; a Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-forest Biomass, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, Co-Innovation Center for Efficient Processing and Utilization of Forest Products, College of Chemical Engineering , Nanjing Forestry University , Nanjing

J Enzyme Inhib Med Chem ; 34(1): 955-972, 2019 Dec.

Article en En | MEDLINE | ID: mdl-31072147

Asunto(s)

Antineoplásicos/farmacología; MAP Quinasa Quinasa 1/antagonistas & inhibidores; Oxadiazoles/farmacología; Inhibidores de Proteínas Quinasas/farmacología; Quinolinas/farmacología; Tiadiazoles/farmacología; Triterpenos/farmacología; Antineoplásicos/síntesis química; Antineoplásicos/química; Apoptosis/efectos de los fármacos; Ciclo Celular/efectos de los fármacos; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Relación Dosis-Respuesta a Droga; Diseño de Fármacos; Ensayos de Selección de Medicamentos Antitumorales; Humanos; MAP Quinasa Quinasa 1/metabolismo; Potencial de la Membrana Mitocondrial/efectos de los fármacos; Modelos Moleculares; Estructura Molecular; Oxadiazoles/química; Inhibidores de Proteínas Quinasas/síntesis química; Inhibidores de Proteínas Quinasas/química; Quinolinas/química; Especies Reactivas de Oxígeno/metabolismo; Relación Estructura-Actividad; Tiadiazoles/química; Triterpenos/química; Ácido Ursólico

Palabras clave

MEK inhibitor; Ursolic acid; antiproliferative activity; apoptosis; quinoline

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oxadiazoles / Quinolinas / Tiadiazoles / Triterpenos / MAP Quinasa Quinasa 1 / Inhibidores de Proteínas Quinasas / Antineoplásicos Límite: Humans Idioma: En Revista: J Enzyme Inhib Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2019 Tipo del documento: Article

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