The role of inflammation in the association between overall and visceral adiposity and subclinical atherosclerosis.
Nutr Metab Cardiovasc Dis
; 29(7): 728-735, 2019 07.
Article
en En
| MEDLINE
| ID: mdl-31138500
ABSTRACT
BACKGROUND AND AIMS:
Inflammation may underlie the association between obesity, atherosclerosis and cardiovascular disease. We investigated to what extent markers of inflammation mediate associations between overall and visceral body fat and subclinical atherosclerosis. METHODS ANDRESULTS:
In this cross-sectional analysis of the Netherlands Epidemiology of Obesity study we estimated total body fat (TBF) by bio-impedance analysis, carotid artery intima media thickness (cIMT) by ultrasound, C-reactive protein (hs-CRP) and glycoprotein acetyls (GlycA) concentrations in fasting blood samples (n = 5627), and visceral adipose tissue (VAT) by magnetic resonance imaging (n = 2247). We examined associations between TBF and VAT, and cIMT using linear regression, adjusted for potential confounding factors, and for mediators cardiometabolic risk factors (blood pressure, glucose and low-density lipoprotein cholesterol), and inflammation using CRP and GlycA as proxies. Mean (SD) cIMT was 615 (90) µm. Per SD of TBF (8%), cIMT was 19 µm larger (95% confidence interval, CI 10, 28). This association was 17 µm (95% CI 8, 27) after adjustment for cardiometabolic risk factors, and did not change after adjustment for markers of inflammation. Per SD (56 cm2) VAT, cIMT was 9 µm larger (95% CI 2, 16) which changed to 5 µm (95% CI -3, 12) after adjustment for cardiometabolic risk factors, and did not change after adjustment for inflammatory markers.CONCLUSION:
Our results suggest that associations between measures of overall and visceral body fat and subclinical atherosclerosis are not mediated by inflammation as measured by CRP and GlycA. Obesity may exert cardiovascular risk via other markers of systemic inflammation.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades de las Arterias Carótidas
/
Mediadores de Inflamación
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Grasa Intraabdominal
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Adiposidad
/
Inflamación
/
Obesidad
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
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Observational_studies
/
Prevalence_studies
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Risk_factors_studies
Límite:
Female
/
Humans
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Male
/
Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
Nutr Metab Cardiovasc Dis
Asunto de la revista:
ANGIOLOGIA
/
CARDIOLOGIA
/
CIENCIAS DA NUTRICAO
/
METABOLISMO
Año:
2019
Tipo del documento:
Article