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Photocontrollable mononegaviruses.
Tahara, Maino; Takishima, Yuto; Miyamoto, Shohei; Nakatsu, Yuichiro; Someya, Kenji; Sato, Moritoshi; Tani, Kenzaburo; Takeda, Makoto.
Afiliación
  • Tahara M; Department of Virology 3, National Institute of Infectious Diseases, Tokyo 208-0011, Japan.
  • Takishima Y; Project Division of ALA Advanced Medical Research, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
  • Miyamoto S; Project Division of ALA Advanced Medical Research, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
  • Nakatsu Y; Department of Virology 3, National Institute of Infectious Diseases, Tokyo 208-0011, Japan.
  • Someya K; Department of Virology 3, National Institute of Infectious Diseases, Tokyo 208-0011, Japan.
  • Sato M; Graduate School of Arts and Sciences, The University of Tokyo, Tokyo 158-8902, Japan.
  • Tani K; Project Division of ALA Advanced Medical Research, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
  • Takeda M; Department of Virology 3, National Institute of Infectious Diseases, Tokyo 208-0011, Japan; mtakeda@nih.go.jp.
Proc Natl Acad Sci U S A ; 116(24): 11587-11589, 2019 06 11.
Article en En | MEDLINE | ID: mdl-31138700
ABSTRACT
Mononegaviruses are promising tools as oncolytic vectors and transgene delivery vectors for gene therapy and regenerative medicine. By using the Magnet proteins, which reversibly heterodimerize upon blue light illumination, photocontrollable mononegaviruses (measles and rabies viruses) were generated. The Magnet proteins were inserted into the flexible domain of viral polymerase, and viruses showed strong replication and oncolytic activities only when the viral polymerases were activated by blue light illumination.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Virus de la Rabia / Virus Oncolíticos / Virus del Sarampión Límite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2019 Tipo del documento: Article País de afiliación: Japón
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Virus de la Rabia / Virus Oncolíticos / Virus del Sarampión Límite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2019 Tipo del documento: Article País de afiliación: Japón