Genetic diversity of HLA system in three populations from Sonora, Mexico: Ciudad Obregón, Hermosillo and rural Sonora.
Hum Immunol
; 81(9): 478-481, 2020 Sep.
Article
en En
| MEDLINE
| ID: mdl-31174914
ABSTRACT
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 439 Mexicans from the state of Sonora living in Ciudad Obregón (Nâ¯=â¯143), Hermosillo (Nâ¯=â¯99), and rural communities (Nâ¯=â¯197) to obtain information regarding allelic and haplotypic frequencies. We find that the 13 most frequent haplotypes for the state of Sonora include nine Native American, three European and one Asian haplotypes. Admixture estimates revealed that the main genetic components in the state of Sonora are European (51.25⯱â¯2.90% by ML; 37.70% of European haplotypes) and Native American (43.35⯱â¯2.57% by ML; 39.64% of Native American haplotypes), while the African genetic component was less apparent (5.39⯱â¯2.54% by ML; 11.04% of African haplotypes).
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Variación Genética
/
Etnicidad
/
Genética de Población
/
Antígenos HLA
Límite:
Humans
País/Región como asunto:
Mexico
Idioma:
En
Revista:
Hum Immunol
Año:
2020
Tipo del documento:
Article
País de afiliación:
México