The VEGF receptor neuropilin 2 promotes homologous recombination by stimulating YAP/TAZ-mediated Rad51 expression.

Elaimy, Ameer L; Amante, John J; Zhu, Lihua Julie; Wang, Mengdie; Walmsley, Charlotte S; FitzGerald, Thomas J; Goel, Hira Lal; Mercurio, Arthur M

Elaimy, Ameer L; Amante, John J; Zhu, Lihua Julie; Wang, Mengdie; Walmsley, Charlotte S; FitzGerald, Thomas J; Goel, Hira Lal; Mercurio, Arthur M.

Afiliación

Elaimy AL; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605.
Amante JJ; Medical Scientist Training Program, University of Massachusetts Medical School, Worcester, MA 01605.
Zhu LJ; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605.
Wang M; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605.
Walmsley CS; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605.
FitzGerald TJ; Department of Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA 01605.
Goel HL; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605.
Mercurio AM; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605.

Proc Natl Acad Sci U S A ; 116(28): 14174-14180, 2019 07 09.

Article en En | MEDLINE | ID: mdl-31235595

Asunto(s)

Neuropilina-2/genética; Recombinasa Rad51/genética; Neoplasias de la Mama Triple Negativas/genética; Factor A de Crecimiento Endotelial Vascular/genética; Proteínas Adaptadoras Transductoras de Señales/genética; Proteína BRCA1/genética; Línea Celular Tumoral; Reparación del ADN/genética; Resistencia a Antineoplásicos/genética; Femenino; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Recombinación Homóloga/genética; Humanos; Neuropilinas/genética; Platino (Metal)/farmacología; Transducción de Señal/efectos de los fármacos; Factores de Transcripción/genética; Neoplasias de la Mama Triple Negativas/patología; Proteínas Señalizadoras YAP

Palabras clave

DNA repair; VEGFneuropilin; YAP/TAZ; breast cancer

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neuropilina-2 / Factor A de Crecimiento Endotelial Vascular / Recombinasa Rad51 / Neoplasias de la Mama Triple Negativas Límite: Female / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2019 Tipo del documento: Article

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