EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2.

Nieminuszczy, Jadwiga; Broderick, Ronan; Bellani, Marina A; Smethurst, Elizabeth; Schwab, Rebekka A; Cherdyntseva, Veronica; Evmorfopoulou, Theodora; Lin, Yea-Lih; Minczuk, Michal; Pasero, Philippe; Gagos, Sarantis; Seidman, Michael M; Niedzwiedz, Wojciech

Nieminuszczy, Jadwiga; Broderick, Ronan; Bellani, Marina A; Smethurst, Elizabeth; Schwab, Rebekka A; Cherdyntseva, Veronica; Evmorfopoulou, Theodora; Lin, Yea-Lih; Minczuk, Michal; Pasero, Philippe; Gagos, Sarantis; Seidman, Michael M; Niedzwiedz, Wojciech.

Afiliación

Nieminuszczy J; The Institute of Cancer Research, London, UK.
Broderick R; The Institute of Cancer Research, London, UK.
Bellani MA; Laboratory of Molecular Gerontology, National Institute on Aging, Baltimore, MD, USA.
Smethurst E; Institute of Molecular Medicine, Oxford, UK.
Schwab RA; Institute of Molecular Medicine, Oxford, UK.
Cherdyntseva V; Laboratory of Genetics, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
Evmorfopoulou T; Laboratory of Genetics, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
Lin YL; Institut de Génétique Humaine, CNRS, Université de Montpellier, Montpellier, France.
Minczuk M; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
Pasero P; Institut de Génétique Humaine, CNRS, Université de Montpellier, Montpellier, France.
Gagos S; Laboratory of Genetics, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
Seidman MM; Laboratory of Molecular Gerontology, National Institute on Aging, Baltimore, MD, USA.
Niedzwiedz W; The Institute of Cancer Research, London, UK. Electronic address: wojciech.niedzwiedz@icr.ac.uk.

Mol Cell ; 75(3): 605-619.e6, 2019 08 08.

Article en En | MEDLINE | ID: mdl-31255466

Asunto(s)

ADN Helicasas/genética; Replicación del ADN/genética; Exodesoxirribonucleasas/genética; RecQ Helicasas/genética; Proteína BRCA1/genética; Proteína BRCA2/genética; Inestabilidad Genómica/genética; Células HeLa; Humanos; Neoplasias/genética; Mutaciones Letales Sintéticas/genética

Palabras clave

BRCA1; BRCA2; DNA replication; EXD2; EXDL2; fork regression

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: ADN Helicasas / Replicación del ADN / Exodesoxirribonucleasas / RecQ Helicasas Límite: Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido

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