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Amyloid-beta impairs insulin signaling by accelerating autophagy-lysosomal degradation of LRP-1 and IR-ß in blood-brain barrier endothelial cells in vitro and in 3XTg-AD mice.
Gali, Chaitanya Chakravarthi; Fanaee-Danesh, Elham; Zandl-Lang, Martina; Albrecher, Nicole Maria; Tam-Amersdorfer, Carmen; Stracke, Anika; Sachdev, Vinay; Reichmann, Florian; Sun, Yidan; Avdili, Afrim; Reiter, Marielies; Kratky, Dagmar; Holzer, Peter; Lass, Achim; Kandimalla, Karunya K; Panzenboeck, Ute.
Afiliación
  • Gali CC; Division of Immunology and Pathophysiology, Otto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Medical University of Graz, Graz, Austria.
  • Fanaee-Danesh E; Division of Immunology and Pathophysiology, Otto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Medical University of Graz, Graz, Austria.
  • Zandl-Lang M; Division of Immunology and Pathophysiology, Otto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Medical University of Graz, Graz, Austria.
  • Albrecher NM; Division of Immunology and Pathophysiology, Otto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Medical University of Graz, Graz, Austria.
  • Tam-Amersdorfer C; Division of Immunology and Pathophysiology, Otto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Medical University of Graz, Graz, Austria.
  • Stracke A; Division of Immunology and Pathophysiology, Otto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Medical University of Graz, Graz, Austria.
  • Sachdev V; Division of Molecular Biology and Biochemistry, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria.
  • Reichmann F; Division of Pharmacology, Otto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Medical University of Graz, Graz, Austria.
  • Sun Y; Division of Immunology and Pathophysiology, Otto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Medical University of Graz, Graz, Austria.
  • Avdili A; Division of Immunology and Pathophysiology, Otto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Medical University of Graz, Graz, Austria.
  • Reiter M; Division of Immunology and Pathophysiology, Otto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Medical University of Graz, Graz, Austria.
  • Kratky D; Division of Molecular Biology and Biochemistry, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria; BioTechMed-Graz, Graz, Austria.
  • Holzer P; Division of Pharmacology, Otto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Medical University of Graz, Graz, Austria.
  • Lass A; Institute of Molecular Biosciences, University of Graz, Graz, Austria; BioTechMed-Graz, Graz, Austria.
  • Kandimalla KK; College of Pharmacy, Department of Pharmaceutics, University of Minnesota, Minneapolis, MN, USA.
  • Panzenboeck U; Division of Immunology and Pathophysiology, Otto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Medical University of Graz, Graz, Austria; BioTechMed-Graz, Graz, Austria. Electronic address: ute.panzenboeck@medunigraz.at.
Mol Cell Neurosci ; 99: 103390, 2019 09.
Article en En | MEDLINE | ID: mdl-31276749
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Receptor de Insulina / Barrera Hematoencefálica / Transducción de Señal / Péptidos beta-Amiloides / Proteína 1 Relacionada con Receptor de Lipoproteína de Baja Densidad / Células Endoteliales / Insulina Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Mol Cell Neurosci Asunto de la revista: BIOLOGIA MOLECULAR / NEUROLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Austria
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Receptor de Insulina / Barrera Hematoencefálica / Transducción de Señal / Péptidos beta-Amiloides / Proteína 1 Relacionada con Receptor de Lipoproteína de Baja Densidad / Células Endoteliales / Insulina Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Mol Cell Neurosci Asunto de la revista: BIOLOGIA MOLECULAR / NEUROLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Austria