Recombinant Subunit Rotavirus Trivalent Vaccine Candidate: Physicochemical Comparisons and Stability Evaluations of Three Protein Antigens.

Agarwal, Sanjeev; Hickey, John M; Sahni, Neha; Toth, Ronald T; Robertson, George A; Sitrin, Robert; Cryz, Stanley; Joshi, Sangeeta B; Volkin, David B

Agarwal, Sanjeev; Hickey, John M; Sahni, Neha; Toth, Ronald T; Robertson, George A; Sitrin, Robert; Cryz, Stanley; Joshi, Sangeeta B; Volkin, David B.

Afiliación

Agarwal S; Department of Pharmaceutical Chemistry, Vaccine Analytics and Formulation Center, University of Kansas, Lawrence, Kansas 66047.
Hickey JM; Department of Pharmaceutical Chemistry, Vaccine Analytics and Formulation Center, University of Kansas, Lawrence, Kansas 66047.
Sahni N; Department of Pharmaceutical Chemistry, Vaccine Analytics and Formulation Center, University of Kansas, Lawrence, Kansas 66047.
Toth RT; Department of Pharmaceutical Chemistry, Vaccine Analytics and Formulation Center, University of Kansas, Lawrence, Kansas 66047.
Robertson GA; The Center for Vaccine Innovation and Access, PATH, Washington, District of Columbia 20001.
Sitrin R; The Center for Vaccine Innovation and Access, PATH, Washington, District of Columbia 20001.
Cryz S; The Center for Vaccine Innovation and Access, PATH, Washington, District of Columbia 20001.
Joshi SB; Department of Pharmaceutical Chemistry, Vaccine Analytics and Formulation Center, University of Kansas, Lawrence, Kansas 66047.
Volkin DB; Department of Pharmaceutical Chemistry, Vaccine Analytics and Formulation Center, University of Kansas, Lawrence, Kansas 66047. Electronic address: volkin@ku.edu.

J Pharm Sci ; 109(1): 380-393, 2020 01.

Article en En | MEDLINE | ID: mdl-31400347

Asunto(s)

Antígenos Virales/genética; Infecciones por Rotavirus/prevención & control; Vacunas contra Rotavirus; Rotavirus/inmunología; Composición de Medicamentos; Estabilidad de Medicamentos; Escherichia coli/genética; Proteínas Recombinantes de Fusión/genética; Vacunas contra Rotavirus/química; Vacunas contra Rotavirus/genética; Vacunas contra Rotavirus/inmunología; Vacunas de Subunidad/química; Vacunas de Subunidad/genética; Vacunas de Subunidad/inmunología; Vacunas Sintéticas/química; Vacunas Sintéticas/genética; Vacunas Sintéticas/inmunología; Proteínas no Estructurales Virales/genética

Palabras clave

aggregation; characterization; formulation; mass spectrometry; rotavirus; stability; vaccine

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Infecciones por Rotavirus / Rotavirus / Vacunas contra Rotavirus / Antígenos Virales Idioma: En Revista: J Pharm Sci Año: 2020 Tipo del documento: Article

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