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The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk.
Deming, Yuetiva; Filipello, Fabia; Cignarella, Francesca; Cantoni, Claudia; Hsu, Simon; Mikesell, Robert; Li, Zeran; Del-Aguila, Jorge L; Dube, Umber; Farias, Fabiana Geraldo; Bradley, Joseph; Budde, John; Ibanez, Laura; Fernandez, Maria Victoria; Blennow, Kaj; Zetterberg, Henrik; Heslegrave, Amanda; Johansson, Per M; Svensson, Johan; Nellgård, Bengt; Lleo, Alberto; Alcolea, Daniel; Clarimon, Jordi; Rami, Lorena; Molinuevo, José Luis; Suárez-Calvet, Marc; Morenas-Rodríguez, Estrella; Kleinberger, Gernot; Ewers, Michael; Harari, Oscar; Haass, Christian; Brett, Thomas J; Benitez, Bruno A; Karch, Celeste M; Piccio, Laura; Cruchaga, Carlos.
Afiliación
  • Deming Y; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Filipello F; Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.
  • Cignarella F; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Cantoni C; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Hsu S; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Mikesell R; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Li Z; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Del-Aguila JL; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Dube U; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Farias FG; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Bradley J; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Budde J; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Ibanez L; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Fernandez MV; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Blennow K; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Zetterberg H; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
  • Heslegrave A; Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden.
  • Johansson PM; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
  • Svensson J; Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden.
  • Nellgård B; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.
  • Lleo A; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.
  • Alcolea D; UK Dementia Research Institute at UCL, London, UK.
  • Clarimon J; Department of Clinical Sciences Helsingborg, Lund University, Lund, Sweden.
  • Rami L; Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Göteborg, Sweden.
  • Molinuevo JL; Department of Anesthesiology, Sahlgrenska University Hospital, Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Göteborg, Sweden.
  • Suárez-Calvet M; Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Morenas-Rodríguez E; Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain.
  • Kleinberger G; Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Ewers M; Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain.
  • Harari O; Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Haass C; Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain.
  • Brett TJ; IDIBAPS, Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, ICN Hospital Clinic, Barcelona, Spain.
  • Benitez BA; IDIBAPS, Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, ICN Hospital Clinic, Barcelona, Spain.
  • Karch CM; Barcelonaßeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.
  • Piccio L; Barcelonaßeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.
  • Cruchaga C; Biomedical Center (BMC), Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany.
Sci Transl Med ; 11(505)2019 08 14.
Article en En | MEDLINE | ID: mdl-31413141
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Glicoproteínas de Membrana / Receptores Inmunológicos / Familia de Multigenes / Enfermedad de Alzheimer / Proteínas de la Membrana Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Female / Humans / Male Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Glicoproteínas de Membrana / Receptores Inmunológicos / Familia de Multigenes / Enfermedad de Alzheimer / Proteínas de la Membrana Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Female / Humans / Male Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos