Low-frequency variants at the <i>CYP2C9</i> locus among Puerto Rican patients on warfarin: <i>in silico</i> predictions of functionality and conservation.

Claudio-Campos, Karla; Moneró-Paredes, Mariangeli; Hernández, Eliud; Renta, Jessicca; Duconge, Jorge

Low-frequency variants at the CYP2C9 locus among Puerto Rican patients on warfarin: in silico predictions of functionality and conservation.

Claudio-Campos, Karla; Moneró-Paredes, Mariangeli; Hernández, Eliud; Renta, Jessicca; Duconge, Jorge.

Afiliación

Claudio-Campos K; Department of Pharmacotherapy & Translational Research, College of Pharmacy, University of Florida, Gainesville, FL 32610-0486, USA.
Moneró-Paredes M; Department of Pharmacology & Toxicology, School of Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, PR 00936-5067, USA.
Hernández E; Department of Pharmaceutical Sciences, Medical Sciences Campus, School of Pharmacy, University of Puerto Rico, San Juan, PR 00936-5067, USA.
Renta J; Department of Biochemistry, School of Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, PR 00936-5067, USA.
Duconge J; Department of Pharmaceutical Sciences, Medical Sciences Campus, School of Pharmacy, University of Puerto Rico, San Juan, PR 00936-5067, USA.

Pharmacogenomics ; 20(12): 891-902, 2019 08.

Article en En | MEDLINE | ID: mdl-31453773

Asunto(s)

Anticoagulantes/efectos adversos; Citocromo P-450 CYP2C9/genética; Hispánicos o Latinos/genética; Polimorfismo de Nucleótido Simple/genética; Warfarina/efectos adversos; Femenino; Frecuencia de los Genes/genética; Genotipo; Humanos; Masculino; Farmacogenética/métodos; Estudios Retrospectivos

Palabras clave

-warfarin; CYP2C9; Caribbean Hispanics; DNA sequencing; docking; pharmacogenetics; single nucleotide variations

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Warfarina / Hispánicos o Latinos / Polimorfismo de Nucleótido Simple / Citocromo P-450 CYP2C9 / Anticoagulantes Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Pharmacogenomics Asunto de la revista: FARMACOLOGIA / GENETICA MEDICA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos

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