Therapeutic effects of JLX-001 on ischemic stroke by inducing autophagy via AMPK-ULK1 signaling pathway in rats.

Ao, Lu-Yao; Li, Wan-Ting; Zhou, Lin; Yan, Yun-Yi; Ye, An-Qi; Liang, Bing-Wen; Shen, Wei-Yang; Zhu, Xiong; Li, Yun-Man

Ao, Lu-Yao; Li, Wan-Ting; Zhou, Lin; Yan, Yun-Yi; Ye, An-Qi; Liang, Bing-Wen; Shen, Wei-Yang; Zhu, Xiong; Li, Yun-Man.

Afiliación

Ao LY; State Key Laboratory of Natural Medicines, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China.
Li WT; State Key Laboratory of Natural Medicines, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China.
Zhou L; State Key Laboratory of Natural Medicines, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China.
Yan YY; State Key Laboratory of Natural Medicines, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China.
Ye AQ; State Key Laboratory of Natural Medicines, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China.
Liang BW; Jiangsu Jinglixin Pharmaceutical Technology Company Limited, Nanjing, 211100, PR China.
Shen WY; School of Sciences, China Pharmaceutical University, Nanjing, 210009, PR China.
Zhu X; Jiangsu Jinglixin Pharmaceutical Technology Company Limited, Nanjing, 211100, PR China. Electronic address: cpuzx@foxmail.com.
Li YM; State Key Laboratory of Natural Medicines, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China. Electronic address: yunmanlicpu@163.com.

Brain Res Bull ; 153: 162-170, 2019 11.

Article en En | MEDLINE | ID: mdl-31472184

Asunto(s)

Autofagia/efectos de los fármacos; Isquemia Encefálica/tratamiento farmacológico; Triterpenos/farmacología; Proteínas Quinasas Activadas por AMP/metabolismo; Animales; Autofagia/fisiología; Homólogo de la Proteína 1 Relacionada con la Autofagia/metabolismo; Edema Encefálico; Infarto de la Arteria Cerebral Media; Masculino; Ratas; Ratas Sprague-Dawley; Transducción de Señal/efectos de los fármacos; Accidente Cerebrovascular/tratamiento farmacológico; Serina-Treonina Quinasas TOR/metabolismo; Triterpenos/uso terapéutico

Palabras clave

AMPK; Autophagy; Ischemic stroke; JLX-001

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Autofagia / Triterpenos / Isquemia Encefálica Límite: Animals Idioma: En Revista: Brain Res Bull Año: 2019 Tipo del documento: Article

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