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Hunterines A-C, Three Unusual Monoterpenoid Indole Alkaloids from Hunteria zeylanica.
Zhang, Jian; Liu, Zhi-Wen; Ao, Yun-Lin; Hu, Li-Jun; Wei, Cui-Jie; Zhang, Qing-Hua; Yuan, Meng-Fei; Wang, Ying; Zhang, Qing-Wen; Ye, Wen-Cai; Zhang, Xiao-Qi.
Afiliación
  • Zhang J; Institute of Traditional Chinese Medicine & Natural Products, and Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research , Jinan University , Guangzhou 510632 , P.R. China.
  • Liu ZW; State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences , University of Macau , Macao SAR , P.R. China.
  • Ao YL; Institute of Traditional Chinese Medicine & Natural Products, and Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research , Jinan University , Guangzhou 510632 , P.R. China.
  • Hu LJ; Institute of Traditional Chinese Medicine & Natural Products, and Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research , Jinan University , Guangzhou 510632 , P.R. China.
  • Wei CJ; Institute of Traditional Chinese Medicine & Natural Products, and Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research , Jinan University , Guangzhou 510632 , P.R. China.
  • Zhang QH; Institute of Traditional Chinese Medicine & Natural Products, and Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research , Jinan University , Guangzhou 510632 , P.R. China.
  • Yuan MF; Institute of Traditional Chinese Medicine & Natural Products, and Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research , Jinan University , Guangzhou 510632 , P.R. China.
  • Wang Y; Institute of Traditional Chinese Medicine & Natural Products, and Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research , Jinan University , Guangzhou 510632 , P.R. China.
  • Zhang QW; Institute of Traditional Chinese Medicine & Natural Products, and Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research , Jinan University , Guangzhou 510632 , P.R. China.
  • Ye WC; State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences , University of Macau , Macao SAR , P.R. China.
  • Zhang XQ; Institute of Traditional Chinese Medicine & Natural Products, and Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research , Jinan University , Guangzhou 510632 , P.R. China.
J Org Chem ; 84(22): 14892-14897, 2019 11 15.
Article en En | MEDLINE | ID: mdl-31475536
ABSTRACT
Three new monoterpenoid indole alkaloids (MIAs), hunterines A-C (1-3), were isolated from Hunteria zeylanica. Compound 1 possesses a unique skeleton with an unprecedented azabicyclo[4.3.1]decane ring system. Compounds 2 and 3 are a pair of epimeric vobasinylindole alkaloid heterodimers. Their structures including absolute configurations were established by spectroscopic analyses, X-ray diffraction, computational calculation, and the modified Mosher's method. Plausible biogenetic pathways of 1-3 were also proposed. Alkaloid 1 showed moderate cytotoxic activity against the HepG2 cell line.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2019 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2019 Tipo del documento: Article