Endophilin A2 regulates calcium-activated chloride channel activity via selective autophagy-mediated TMEM16A degradation.

Liu, Can-Zhao; Li, Fei-Ya; Lv, Xiao-Fei; Ma, Ming-Ming; Li, Xiang-Yu; Lin, Cai-Xia; Wang, Guan-Lei; Guan, Yong-Yuan

Liu, Can-Zhao; Li, Fei-Ya; Lv, Xiao-Fei; Ma, Ming-Ming; Li, Xiang-Yu; Lin, Cai-Xia; Wang, Guan-Lei; Guan, Yong-Yuan.

Afiliación

Liu CZ; Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China. liucanzhao0521@163.com.
Li FY; Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Lv XF; Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Ma MM; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Li XY; Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Lin CX; Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Wang GL; Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Guan YY; Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.

Acta Pharmacol Sin ; 41(2): 208-217, 2020 Feb.

Article en En | MEDLINE | ID: mdl-31484993

Asunto(s)

Aciltransferasas/metabolismo; Anoctamina-1/metabolismo; Calcio/metabolismo; Canales de Cloruro/metabolismo; Aciltransferasas/genética; Angiotensina II/metabolismo; Animales; Autofagia/fisiología; Células Cultivadas; Regulación hacia Abajo; Técnicas de Silenciamiento del Gen; Hipertensión/fisiopatología; Masculino; Miocitos del Músculo Liso/metabolismo; Ratas; Ratas Sprague-Dawley; Remodelación Vascular/fisiología

Palabras clave

Ca2+-activated chloride channel; TMEM16A; angiotensin II; autophagy; basilar smooth muscle cells; endophilin A2; hypertension; ubiquitination; vascular remodeling

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Aciltransferasas / Calcio / Canales de Cloruro / Anoctamina-1 Límite: Animals Idioma: En Revista: Acta Pharmacol Sin Asunto de la revista: FARMACOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: China

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