Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5-Inhibitor Complexes.

Indorato, Rose-Laure; Talapatra, Sandeep K; Lin, Fangzhu; Haider, Shozeb; Mackay, Simon P; Kozielski, Frank; Skoufias, Dimitrios A

Indorato, Rose-Laure; Talapatra, Sandeep K; Lin, Fangzhu; Haider, Shozeb; Mackay, Simon P; Kozielski, Frank; Skoufias, Dimitrios A.

Afiliación

Indorato RL; Université Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale (IBS), Grenoble, France.
Talapatra SK; Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, London, United Kingdom.
Lin F; Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, London, United Kingdom.
Haider S; Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, London, United Kingdom.
Mackay SP; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom.
Kozielski F; Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, London, United Kingdom. dimitrios.skoufias@ibs.fr f.kozielski@ucl.ac.uk.
Skoufias DA; Université Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale (IBS), Grenoble, France. dimitrios.skoufias@ibs.fr f.kozielski@ucl.ac.uk.

Mol Cancer Ther ; 18(12): 2394-2406, 2019 12.

Article en En | MEDLINE | ID: mdl-31488701

Asunto(s)

Antimitóticos/uso terapéutico; Tiadiazoles/uso terapéutico; Antimitóticos/farmacología; Técnicas de Cultivo de Célula; Humanos; Modelos Moleculares; Tiadiazoles/farmacología

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tiadiazoles / Antimitóticos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Mol Cancer Ther Asunto de la revista: ANTINEOPLASICOS Año: 2019 Tipo del documento: Article País de afiliación: Francia

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