Molecular epidemiology of carbapenem-resistance plasmids using publicly available sequences.
Genome
; 62(12): 785-792, 2019 Dec.
Article
en En
| MEDLINE
| ID: mdl-31491336
ABSTRACT
Carbapenem-resistant bacteria have quickly become a worldwide concern in nosocomial infections. Of the seven known carbapenemases, four have been shown to be particularly problematic KPC, NDM, IMP, and VIM. To date, many local and species- or carbapenemase-specific epidemiological studies have been performed, which often focus on the organism itself. This report attempts to perform an inclusive (encompass both species and carbapenemase) epidemiologic study using publicly available plasmid sequences from NCBI. In this report, the gene content of these various plasmids has been characterized, replicon types of the plasmids identified, and the global spread and species promiscuity of the plasmids analyzed. Additionally, support to several groups targeting plasmid maintenance and transfer mechanisms to slow the spread of resistance plasmids is given.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Plásmidos
/
Proteínas Bacterianas
/
Beta-Lactamasas
/
Farmacorresistencia Bacteriana
Tipo de estudio:
Screening_studies
País/Región como asunto:
America do norte
/
Asia
Idioma:
En
Revista:
Genome
Asunto de la revista:
GENETICA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos