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Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics.
Borsari, Chiara; Jiménez-Antón, María Dolores; Eick, Julia; Bifeld, Eugenia; Torrado, Juan José; Olías-Molero, Ana Isabel; Corral, María Jesús; Santarem, Nuno; Baptista, Catarina; Severi, Leda; Gul, Sheraz; Wolf, Markus; Kuzikov, Maria; Ellinger, Bernhard; Reinshagen, Jeanette; Witt, Gesa; Linciano, Pasquale; Tait, Annalisa; Costantino, Luca; Luciani, Rosaria; Tejera Nevado, Paloma; Zander-Dinse, Dorothea; Franco, Caio H; Ferrari, Stefania; Moraes, Carolina B; Cordeiro-da-Silva, Anabela; Ponterini, Glauco; Clos, Joachim; Alunda, José María; Costi, Maria Paola.
Afiliación
  • Borsari C; University of Modena and Reggio Emilia, Via Campi 103, 41125, Modena, Italy.
  • Jiménez-Antón MD; Complutense University of Madrid, 28040, Madrid, Spain; Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain.
  • Eick J; Bernhard Nocht Institute for Tropical Medicine, D-20359, Hamburg, Germany.
  • Bifeld E; Bernhard Nocht Institute for Tropical Medicine, D-20359, Hamburg, Germany.
  • Torrado JJ; Complutense University of Madrid, 28040, Madrid, Spain.
  • Olías-Molero AI; Complutense University of Madrid, 28040, Madrid, Spain; Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain.
  • Corral MJ; Complutense University of Madrid, 28040, Madrid, Spain; Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain.
  • Santarem N; Instituto de Investigação e Inovação em Saúde, Universidade do Porto and Institute for Molecular and Cell Biology, University of Porto, 4150-180, Porto, Portugal.
  • Baptista C; Instituto de Investigação e Inovação em Saúde, Universidade do Porto and Institute for Molecular and Cell Biology, University of Porto, 4150-180, Porto, Portugal.
  • Severi L; University of Modena and Reggio Emilia, Via Campi 103, 41125, Modena, Italy.
  • Gul S; Fraunhofer Institute for Molecular Biology and Applied Ecology Screening Port, Hamburg, Germany.
  • Wolf M; Fraunhofer Institute for Molecular Biology and Applied Ecology Screening Port, Hamburg, Germany.
  • Kuzikov M; Fraunhofer Institute for Molecular Biology and Applied Ecology Screening Port, Hamburg, Germany.
  • Ellinger B; Fraunhofer Institute for Molecular Biology and Applied Ecology Screening Port, Hamburg, Germany.
  • Reinshagen J; Fraunhofer Institute for Molecular Biology and Applied Ecology Screening Port, Hamburg, Germany.
  • Witt G; Fraunhofer Institute for Molecular Biology and Applied Ecology Screening Port, Hamburg, Germany.
  • Linciano P; University of Modena and Reggio Emilia, Via Campi 103, 41125, Modena, Italy.
  • Tait A; University of Modena and Reggio Emilia, Via Campi 103, 41125, Modena, Italy.
  • Costantino L; University of Modena and Reggio Emilia, Via Campi 103, 41125, Modena, Italy.
  • Luciani R; University of Modena and Reggio Emilia, Via Campi 103, 41125, Modena, Italy.
  • Tejera Nevado P; Bernhard Nocht Institute for Tropical Medicine, D-20359, Hamburg, Germany.
  • Zander-Dinse D; Bernhard Nocht Institute for Tropical Medicine, D-20359, Hamburg, Germany.
  • Franco CH; Laboratório Nacional de Biociências (LNBio), Centro Nacional de Pesquisaem Energia e Materiais (CNPEM), 13083-100, Campinas, SP, Brazil.
  • Ferrari S; University of Modena and Reggio Emilia, Via Campi 103, 41125, Modena, Italy.
  • Moraes CB; Laboratório Nacional de Biociências (LNBio), Centro Nacional de Pesquisaem Energia e Materiais (CNPEM), 13083-100, Campinas, SP, Brazil.
  • Cordeiro-da-Silva A; Instituto de Investigação e Inovação em Saúde, Universidade do Porto and Institute for Molecular and Cell Biology, University of Porto, 4150-180, Porto, Portugal; Departamento de Ciências Biológicas, Faculdade de Farmácia da Universidade do Porto (FFUP), Porto, Portugal.
  • Ponterini G; University of Modena and Reggio Emilia, Via Campi 103, 41125, Modena, Italy.
  • Clos J; Bernhard Nocht Institute for Tropical Medicine, D-20359, Hamburg, Germany. Electronic address: clos@bni-hamburg.de.
  • Alunda JM; Complutense University of Madrid, 28040, Madrid, Spain; Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain. Electronic address: jmalunda@ucm.es.
  • Costi MP; University of Modena and Reggio Emilia, Via Campi 103, 41125, Modena, Italy. Electronic address: mariapaola.costi@unimore.it.
Eur J Med Chem ; 183: 111676, 2019 Dec 01.
Article en En | MEDLINE | ID: mdl-31542713
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fosforilcolina / Tiofenos / Leishmaniasis / Flavonoles / Leishmania / Antiprotozoarios Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Animals / Humans Idioma: En Revista: Eur J Med Chem Año: 2019 Tipo del documento: Article País de afiliación: Italia
Texto completo
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XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fosforilcolina / Tiofenos / Leishmaniasis / Flavonoles / Leishmania / Antiprotozoarios Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Animals / Humans Idioma: En Revista: Eur J Med Chem Año: 2019 Tipo del documento: Article País de afiliación: Italia