Infection profile in children and adolescents with bone marrow failures treated with allogeneic hematopoietic stem cell transplantation.
Pediatr Transplant
; 23(8): e13592, 2019 12.
Article
en En
| MEDLINE
| ID: mdl-31587440
ABSTRACT
BACKGROUND:
The objective of the study was to analyze the profile of infections in children with BMF following alloHCT.METHODS:
Data of 169 consecutive children with inherited and acquired BMF treated with alloHCT between 2012 and 2017 in Polish pediatric transplant departments were analyzed in registry-based retrospective study, with respect to the type of infection, and clinical outcome.RESULTS:
At least 1 infection was diagnosed in 107/169 patients (60.4%). In total, 182 infections were diagnosed. The most common were VI (96; 52.7%), followed by BI (71; 39.0%), and FI (15; 8.2%), P < .001. The most common etiological factors of VI were as follows CMV (38.5%), EBV (22.9%), and BK virus (24%); while of BI were as follows Staphylococcus spp. (17; 23.9%), Enterococcus faecium (10; 14.1%), and Klebsiella pneumoniae (9; 12.7%). No difference was found between the occurrence of infections with respect to donor type, graft source, and conditioning type. GvHD had no impact on the incidence of VI, BI, and FI. Fifteen FI were diagnosed in 12 patients, of which 14 FI were diagnosed in children transplanted for FA. Of total 107 children, 9 died (8.4%), of which 4 (3.7%) due to infections bacterial sepsis (2) and invasive FI (2).CONCLUSION:
Infections in children with BMF following alloHCT remain an important cause of morbidity. Children with FA had high incidence of FI. In our analysis, aGvHD had no impact on the occurrence on infections, although the study was not strong enough to prove such a difference.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Complicaciones Posoperatorias
/
Trasplante de Células Madre Hematopoyéticas
/
Trastornos de Fallo de la Médula Ósea
/
Infecciones
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
Pediatr Transplant
Asunto de la revista:
PEDIATRIA
/
TRANSPLANTE
Año:
2019
Tipo del documento:
Article
País de afiliación:
Polonia