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Environmental stimuli drive a transition from cooperation to competition in synthetic phototrophic communities.
Zuñiga, Cristal; Li, Chien-Ting; Yu, Geng; Al-Bassam, Mahmoud M; Li, Tingting; Jiang, Liqun; Zaramela, Livia S; Guarnieri, Michael; Betenbaugh, Michael J; Zengler, Karsten.
Afiliación
  • Zuñiga C; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
  • Li CT; Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD, USA.
  • Yu G; Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD, USA.
  • Al-Bassam MM; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
  • Li T; Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD, USA.
  • Jiang L; Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD, USA.
  • Zaramela LS; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
  • Guarnieri M; National Bioenergy Center, National Renewable Energy Laboratory, Golden, CO, USA.
  • Betenbaugh MJ; Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD, USA.
  • Zengler K; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA. kzengler@ucsd.edu.
Nat Microbiol ; 4(12): 2184-2191, 2019 12.
Article en En | MEDLINE | ID: mdl-31591554
ABSTRACT
Phototrophic communities of photosynthetic algae or cyanobacteria and heterotrophic bacteria or fungi are pervasive throughout the environment1. How interactions between members contribute to the resilience and affect the fitness of phototrophic communities is not fully understood2,3. Here, we integrated metatranscriptomics, metabolomics and phenotyping with computational modelling to reveal condition-dependent secretion and cross-feeding of metabolites in a synthetic community. We discovered that interactions between members are highly dynamic and are driven by the availability of organic and inorganic nutrients. Environmental factors, such as ammonia concentration, influenced community stability by shifting members from collaborating to competing. Furthermore, overall fitness was dependent on genotype and streamlined genomes improved growth of the entire community. Our mechanistic framework provides insights into the physiology and metabolic response to environmental and genetic perturbation of these ubiquitous microbial associations.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fotosíntesis / Ambiente / Microbiología Ambiental / Procesos Heterotróficos / Metabolómica / Interacciones Microbianas Tipo de estudio: Prognostic_studies Idioma: En Revista: Nat Microbiol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fotosíntesis / Ambiente / Microbiología Ambiental / Procesos Heterotróficos / Metabolómica / Interacciones Microbianas Tipo de estudio: Prognostic_studies Idioma: En Revista: Nat Microbiol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos