Intracellular Pharmacodynamic Modeling Is Predictive of the Clinical Activity of Fluoroquinolones against Tuberculosis.

Donnellan, Samantha; Aljayyoussi, Ghaith; Moyo, Emmanuel; Ardrey, Alison; Martinez-Rodriguez, Carmen; Ward, Stephen A; Biagini, Giancarlo A

Donnellan, Samantha; Aljayyoussi, Ghaith; Moyo, Emmanuel; Ardrey, Alison; Martinez-Rodriguez, Carmen; Ward, Stephen A; Biagini, Giancarlo A.

Afiliación

Donnellan S; Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom.
Aljayyoussi G; Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom.
Moyo E; Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom.
Ardrey A; Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom.
Martinez-Rodriguez C; Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom.
Ward SA; Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom.
Biagini GA; Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom giancarlo.biagini@lstmed.ac.uk.

Antimicrob Agents Chemother ; 64(1)2019 12 20.

Article en En | MEDLINE | ID: mdl-31611354

Asunto(s)

Antituberculosos/farmacología; Antituberculosos/farmacocinética; Fluoroquinolonas/farmacología; Fluoroquinolonas/farmacocinética; Modelos Biológicos; Tuberculosis Pulmonar/tratamiento farmacológico; Tuberculosis Pulmonar/metabolismo; Línea Celular; Simulación por Computador; Técnicas de Apoyo para la Decisión; Desarrollo de Medicamentos; Humanos; Macrófagos/efectos de los fármacos; Macrófagos/microbiología; Método de Montecarlo; Moxifloxacino/farmacocinética; Moxifloxacino/farmacología; Mycobacterium tuberculosis/efectos de los fármacos; Células THP-1; Tuberculosis Resistente a Múltiples Medicamentos/tratamiento farmacológico; Tuberculosis Resistente a Múltiples Medicamentos/metabolismo

Palabras clave

PDi; infectious disease; pharmacodynamics; pharmacokinetics; preclinical drug studies; tuberculosis

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tuberculosis Pulmonar / Fluoroquinolonas / Modelos Biológicos / Antituberculosos Tipo de estudio: Health_economic_evaluation / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Antimicrob Agents Chemother Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido

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