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Synergistic growth inhibition mediated by dual PI3K/mTOR pathway targeting and genetic or direct pharmacological AKT inhibition in human glioblastoma models.
von Achenbach, Caroline; Weller, Michael; Kaulich, Kerstin; Gramatzki, Dorothee; Zacher, Angela; Fabbro, Doriano; Reifenberger, Guido; Szabó, Emese.
Afiliación
  • von Achenbach C; Laboratory of Molecular Neuro-Oncology, Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland.
  • Weller M; Laboratory of Molecular Neuro-Oncology, Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland.
  • Kaulich K; Institute of Neuropathology, Heinrich Heine University, Düsseldorf, and German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, Düsseldorf, Germany.
  • Gramatzki D; Laboratory of Molecular Neuro-Oncology, Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland.
  • Zacher A; Institute of Neuropathology, Heinrich Heine University, Düsseldorf, and German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, Düsseldorf, Germany.
  • Fabbro D; PIQUR Therapeutics AG, Basel, Switzerland.
  • Reifenberger G; Institute of Neuropathology, Heinrich Heine University, Düsseldorf, and German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, Düsseldorf, Germany.
  • Szabó E; Laboratory of Molecular Neuro-Oncology, Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland.
J Neurochem ; 153(4): 510-524, 2020 05.
Article en En | MEDLINE | ID: mdl-31618458
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Sistemas de Liberación de Medicamentos / Glioblastoma / Fosfatidilinositol 3-Quinasas / Silenciador del Gen / Proteínas Proto-Oncogénicas c-akt / Serina-Treonina Quinasas TOR Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: J Neurochem Año: 2020 Tipo del documento: Article País de afiliación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Sistemas de Liberación de Medicamentos / Glioblastoma / Fosfatidilinositol 3-Quinasas / Silenciador del Gen / Proteínas Proto-Oncogénicas c-akt / Serina-Treonina Quinasas TOR Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: J Neurochem Año: 2020 Tipo del documento: Article País de afiliación: Suiza