Protein tyrosine phosphatase receptor type R (PTPRR) antagonizes the Wnt signaling pathway in ovarian cancer by dephosphorylating and inactivating ß-catenin.

Wang, Yuetong; Cao, Jian; Liu, Weiwei; Zhang, Jiali; Wang, Zuo; Zhang, Yiqun; Hou, Linjun; Chen, Shengmiao; Hao, Piliang; Zhang, Liye; Zhuang, Min; Yu, Yang; Li, Dake; Fan, Gaofeng

Wang, Yuetong; Cao, Jian; Liu, Weiwei; Zhang, Jiali; Wang, Zuo; Zhang, Yiqun; Hou, Linjun; Chen, Shengmiao; Hao, Piliang; Zhang, Liye; Zhuang, Min; Yu, Yang; Li, Dake; Fan, Gaofeng.

Afiliación

Wang Y; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Cao J; Department of Gynecology, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing 210004, China.
Liu W; Institute of Biophysics, Key Laboratory of RNA Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing 100101, China.
Zhang J; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Wang Z; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Zhang Y; Institute of Biophysics, Key Laboratory of RNA Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing 100101, China.
Hou L; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Chen S; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Hao P; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Zhang L; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Zhuang M; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Yu Y; Institute of Biophysics, Key Laboratory of RNA Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing 100101, China.
Li D; Department of Gynecology, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing 210004, China. Electronic address: lidake2002@163.com.
Fan G; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. Electronic address: fangf@shanghaitech.edu.cn.

J Biol Chem ; 294(48): 18306-18323, 2019 11 29.

Article en En | MEDLINE | ID: mdl-31653698

Asunto(s)

Neoplasias Ováricas/genética; Proteínas Tirosina Fosfatasas Clase 7 Similares a Receptores/genética; Vía de Señalización Wnt/genética; beta Catenina/genética; Animales; Línea Celular; Línea Celular Tumoral; Femenino; Perfilación de la Expresión Génica; Regulación Neoplásica de la Expresión Génica; Células HEK293; Humanos; Ratones Desnudos; Neoplasias Ováricas/metabolismo; Neoplasias Ováricas/patología; Fosforilación; Interferencia de ARN; Tratamiento con ARN de Interferencia/métodos; Proteínas Tirosina Fosfatasas Clase 7 Similares a Receptores/metabolismo; Análisis de Supervivencia; Ensayos Antitumor por Modelo de Xenoinjerto/métodos; beta Catenina/metabolismo

Palabras clave

Wnt signaling; beta-catenin; epigenetics; gene regulation; ovarian cancer; phosphatase; protein tyrosine phosphatase receptor type R (PTPRR); signal transduction; tumor suppressor gene; tyrosine phosphorylation

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Beta Catenina / Proteínas Tirosina Fosfatasas Clase 7 Similares a Receptores / Vía de Señalización Wnt Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: J Biol Chem Año: 2019 Tipo del documento: Article País de afiliación: China

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