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CDK4/CDK6 inhibition as a novel strategy to suppress the growth and survival of BCR-ABL1T315I+ clones in TKI-resistant CML.
Schneeweiss-Gleixner, Mathias; Byrgazov, Konstantin; Stefanzl, Gabriele; Berger, Daniela; Eisenwort, Gregor; Lucini, Chantal Blanche; Herndlhofer, Susanne; Preuner, Sandra; Obrova, Klara; Pusic, Petra; Witzeneder, Nadine; Greiner, Georg; Hoermann, Gregor; Sperr, Wolfgang R; Lion, Thomas; Deininger, Michael; Valent, Peter; Gleixner, Karoline V.
Afiliación
  • Schneeweiss-Gleixner M; Department of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria; Ludwig Boltzmann Institute for Hematology & Oncology, Medical University of Vienna, Austria.
  • Byrgazov K; Children's Cancer Research Institute (CCRI), Vienna, Austria.
  • Stefanzl G; Ludwig Boltzmann Institute for Hematology & Oncology, Medical University of Vienna, Austria.
  • Berger D; Ludwig Boltzmann Institute for Hematology & Oncology, Medical University of Vienna, Austria.
  • Eisenwort G; Department of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria; Ludwig Boltzmann Institute for Hematology & Oncology, Medical University of Vienna, Austria.
  • Lucini CB; Children's Cancer Research Institute (CCRI), Vienna, Austria.
  • Herndlhofer S; Department of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria; Ludwig Boltzmann Institute for Hematology & Oncology, Medical University of Vienna, Austria.
  • Preuner S; Children's Cancer Research Institute (CCRI), Vienna, Austria.
  • Obrova K; Children's Cancer Research Institute (CCRI), Vienna, Austria.
  • Pusic P; Children's Cancer Research Institute (CCRI), Vienna, Austria.
  • Witzeneder N; Ludwig Boltzmann Institute for Hematology & Oncology, Medical University of Vienna, Austria; Department of Laboratory Medicine, Medical University of Vienna, Austria.
  • Greiner G; Ludwig Boltzmann Institute for Hematology & Oncology, Medical University of Vienna, Austria; Department of Laboratory Medicine, Medical University of Vienna, Austria.
  • Hoermann G; Ludwig Boltzmann Institute for Hematology & Oncology, Medical University of Vienna, Austria; Department of Laboratory Medicine, Medical University of Vienna, Austria; Central Institute of Medical and Chemical Laboratory Diagnostics, University Hospital Innsbruck, Austria.
  • Sperr WR; Department of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria; Ludwig Boltzmann Institute for Hematology & Oncology, Medical University of Vienna, Austria.
  • Lion T; Children's Cancer Research Institute (CCRI), Vienna, Austria.
  • Deininger M; Division of Hematology and Hematologic Malignancies, Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA.
  • Valent P; Department of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria; Ludwig Boltzmann Institute for Hematology & Oncology, Medical University of Vienna, Austria. Electronic address: peter.valent@meduniwien.a
  • Gleixner KV; Department of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria; Ludwig Boltzmann Institute for Hematology & Oncology, Medical University of Vienna, Austria. Electronic address: karoline.gleixner@meduniw
EBioMedicine ; 50: 111-121, 2019 Dec.
Article en En | MEDLINE | ID: mdl-31761618
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Leucemia Mielógena Crónica BCR-ABL Positiva / Proteínas de Fusión bcr-abl / Resistencia a Antineoplásicos / Inhibidores de Proteínas Quinasas / Quinasa 4 Dependiente de la Ciclina / Quinasa 6 Dependiente de la Ciclina / Mutación Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: EBioMedicine Año: 2019 Tipo del documento: Article País de afiliación: Austria
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Leucemia Mielógena Crónica BCR-ABL Positiva / Proteínas de Fusión bcr-abl / Resistencia a Antineoplásicos / Inhibidores de Proteínas Quinasas / Quinasa 4 Dependiente de la Ciclina / Quinasa 6 Dependiente de la Ciclina / Mutación Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: EBioMedicine Año: 2019 Tipo del documento: Article País de afiliación: Austria