An improved, scalable synthesis of Notum inhibitor LP-922056 using 1-chloro-1,2-benziodoxol-3-one as a superior electrophilic chlorinating agent.

Willis, Nicky J; Bayle, Elliott D; Papageorgiou, George; Steadman, David; Atkinson, Benjamin N; Mahy, William; Fish, Paul V

Willis, Nicky J; Bayle, Elliott D; Papageorgiou, George; Steadman, David; Atkinson, Benjamin N; Mahy, William; Fish, Paul V.

Afiliación

Willis NJ; Alzheimer's Research UK UCL Drug Discovery Institute, The Cruciform Building, University College London, Gower Street, London WC1E 6BT, UK.
Bayle ED; Alzheimer's Research UK UCL Drug Discovery Institute, The Cruciform Building, University College London, Gower Street, London WC1E 6BT, UK.
Papageorgiou G; The Francis Crick Institute, 1 Midland Road, Kings Cross, London NW1 1AT, UK.
Steadman D; The Francis Crick Institute, 1 Midland Road, Kings Cross, London NW1 1AT, UK.
Atkinson BN; Alzheimer's Research UK UCL Drug Discovery Institute, The Cruciform Building, University College London, Gower Street, London WC1E 6BT, UK.
Mahy W; Alzheimer's Research UK UCL Drug Discovery Institute, The Cruciform Building, University College London, Gower Street, London WC1E 6BT, UK.
Fish PV; Alzheimer's Research UK UCL Drug Discovery Institute, The Cruciform Building, University College London, Gower Street, London WC1E 6BT, UK.

Beilstein J Org Chem ; 15: 2790-2797, 2019.

Article en En | MEDLINE | ID: mdl-31807213

Palabras clave

1-chloro-1,2-benziodoxol-3-one; LP-922056; Notum inhibitor; brain penetration; electrophilic chlorination

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Beilstein J Org Chem Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido

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