T618I CSF3R mutations in chronic neutrophilic leukemia induce oncogenic signals through aberrant trafficking and constitutive phosphorylation of the O-glycosylated receptor form.

Price, Andrea; Druhan, Lawrence J; Lance, Amanda; Clark, Gavin; Vestal, C Greer; Zhang, Qing; Foureau, David; Parsons, Judy; Hamilton, Alicia; Steuerwald, Nury M; Avalos, Belinda R

Price, Andrea; Druhan, Lawrence J; Lance, Amanda; Clark, Gavin; Vestal, C Greer; Zhang, Qing; Foureau, David; Parsons, Judy; Hamilton, Alicia; Steuerwald, Nury M; Avalos, Belinda R.

Afiliación

Price A; Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Atrium Health, Charlotte, NC, USA.
Druhan LJ; Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Atrium Health, Charlotte, NC, USA.
Lance A; Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Atrium Health, Charlotte, NC, USA.
Clark G; Cornell University, Ithaca, NY, USA.
Vestal CG; Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Atrium Health, Charlotte, NC, USA.
Zhang Q; Department of Cancer Biostatistics, Levine Cancer Institute, Atrium Health, Charlotte, NC, USA.
Foureau D; Immune Monitoring Core Laboratory, Levine Cancer Institute, Atrium Health, Charlotte, NC, USA.
Parsons J; Molecular Biology and Genomics Laboratory, Levine Cancer Institute, Atrium Health, Charlotte, NC, USA.
Hamilton A; Molecular Biology and Genomics Laboratory, Levine Cancer Institute, Atrium Health, Charlotte, NC, USA.
Steuerwald NM; Molecular Biology and Genomics Laboratory, Levine Cancer Institute, Atrium Health, Charlotte, NC, USA.
Avalos BR; Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Atrium Health, Charlotte, NC, USA. Electronic address: belinda.avalos@atriumhealth.org.

Biochem Biophys Res Commun ; 523(1): 208-213, 2020 02 26.

Article en En | MEDLINE | ID: mdl-31848046

Asunto(s)

Leucemia Neutrofílica Crónica/genética; Oncogenes/genética; Receptores del Factor Estimulante de Colonias/metabolismo; Transducción de Señal/genética; Animales; Células Cultivadas; Glicosilación; Leucemia Neutrofílica Crónica/metabolismo; Leucemia Neutrofílica Crónica/patología; Ratones; Mutación; Fosforilación; Receptores del Factor Estimulante de Colonias/genética

Palabras clave

Chronic neutrophilic leukemia; Glycosylation; Granulocyte-colony stimulating factor receptor; Ubiquitination

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oncogenes / Leucemia Neutrofílica Crónica / Transducción de Señal / Receptores del Factor Estimulante de Colonias Límite: Animals Idioma: En Revista: Biochem Biophys Res Commun Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google