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GDF15 mediates the effects of metformin on body weight and energy balance.
Coll, Anthony P; Chen, Michael; Taskar, Pranali; Rimmington, Debra; Patel, Satish; Tadross, John A; Cimino, Irene; Yang, Ming; Welsh, Paul; Virtue, Samuel; Goldspink, Deborah A; Miedzybrodzka, Emily L; Konopka, Adam R; Esponda, Raul Ruiz; Huang, Jeffrey T-J; Tung, Y C Loraine; Rodriguez-Cuenca, Sergio; Tomaz, Rute A; Harding, Heather P; Melvin, Audrey; Yeo, Giles S H; Preiss, David; Vidal-Puig, Antonio; Vallier, Ludovic; Nair, K Sreekumaran; Wareham, Nicholas J; Ron, David; Gribble, Fiona M; Reimann, Frank; Sattar, Naveed; Savage, David B; Allan, Bernard B; O'Rahilly, Stephen.
Afiliación
  • Coll AP; MRC Metabolic Diseases Unit, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK. apc36@cam.ac.uk.
  • Chen M; NGM Biopharmaceuticals, South San Francisco, CA, USA.
  • Taskar P; NGM Biopharmaceuticals, South San Francisco, CA, USA.
  • Rimmington D; MRC Metabolic Diseases Unit, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
  • Patel S; MRC Metabolic Diseases Unit, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
  • Tadross JA; MRC Metabolic Diseases Unit, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
  • Cimino I; MRC Metabolic Diseases Unit, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
  • Yang M; MRC Metabolic Diseases Unit, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
  • Welsh P; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
  • Virtue S; MRC Metabolic Diseases Unit, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
  • Goldspink DA; MRC Metabolic Diseases Unit, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
  • Miedzybrodzka EL; MRC Metabolic Diseases Unit, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
  • Konopka AR; Division of Endocrinology, Mayo Clinic, Rochester, MN, USA.
  • Esponda RR; Division of Endocrinology, Mayo Clinic, Rochester, MN, USA.
  • Huang JT; Division of Systems Medicine, School of Medicine, University of Dundee, Dundee, UK.
  • Tung YCL; MRC Metabolic Diseases Unit, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
  • Rodriguez-Cuenca S; MRC Metabolic Diseases Unit, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
  • Tomaz RA; Wellcome -Medical Research Council Cambridge Stem Cell Institute, Department of Surgery, University of Cambridge, Cambridge, UK.
  • Harding HP; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
  • Melvin A; MRC Metabolic Diseases Unit, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
  • Yeo GSH; MRC Metabolic Diseases Unit, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
  • Preiss D; MRC Population Health Research Unit, Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
  • Vidal-Puig A; MRC Metabolic Diseases Unit, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
  • Vallier L; Wellcome -Medical Research Council Cambridge Stem Cell Institute, Department of Surgery, University of Cambridge, Cambridge, UK.
  • Nair KS; Division of Endocrinology, Mayo Clinic, Rochester, MN, USA.
  • Wareham NJ; MRC Epidemiology Unit, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
  • Ron D; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
  • Gribble FM; MRC Metabolic Diseases Unit, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
  • Reimann F; MRC Metabolic Diseases Unit, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
  • Sattar N; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
  • Savage DB; MRC Metabolic Diseases Unit, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
  • Allan BB; NGM Biopharmaceuticals, South San Francisco, CA, USA.
  • O'Rahilly S; MRC Metabolic Diseases Unit, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK. so104@medschl.cam.ac.uk.
Nature ; 578(7795): 444-448, 2020 02.
Article en En | MEDLINE | ID: mdl-31875646
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Peso Corporal / Metabolismo Energético / Factor 15 de Diferenciación de Crecimiento / Metformina Tipo de estudio: Clinical_trials Límite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Nature Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Peso Corporal / Metabolismo Energético / Factor 15 de Diferenciación de Crecimiento / Metformina Tipo de estudio: Clinical_trials Límite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Nature Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido