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Enantiomeric pairs of meroterpenoids from Rhododendron fastigiatum.
Huang, Guang-Hui; Lei, Chun; Zhu, Ke-Xin; Li, Jing-Ya; Li, Jia; Hou, Ai-Jun.
Afiliación
  • Huang GH; School of Pharmacy, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 201203, China.
  • Lei C; School of Pharmacy, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 201203, China. Electronic address: chunlei@fudan.edu.cn.
  • Zhu KX; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Li JY; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Li J; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Hou AJ; School of Pharmacy, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 201203, China. Electronic address: ajhou@shmu.edu.cn.
Chin J Nat Med ; 17(12): 963-969, 2019 Dec.
Article en En | MEDLINE | ID: mdl-31882052
ABSTRACT
Five pairs of optically pure meroterpenoid enantiomers (1a/1b-5a/5b) and two known compounds (6 and 7) were isolated from Rhododendron fastigiatum. Compounds 1a/1b-5a/5b were resolved from naturally scalemic mixtures by chiral HPLC. Their structures were elucidated by spectroscopic methods, X-ray crystallographic experiments, and ECD analyses. Compounds 1a/1b, 2a/2b, 3b, 4a/4b, and 5a/5b were new meroterpenoids with different polycyclic systems. Two enantiomeric pairs (2a/2b and 3a/3b), 6, and 7 exhibited inhibitory effects on protein tyrosine phosphatase 1B (PTP1B) in vitro.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Terpenos / Rhododendron / Proteína Tirosina Fosfatasa no Receptora Tipo 1 País/Región como asunto: Asia Idioma: En Revista: Chin J Nat Med Año: 2019 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Terpenos / Rhododendron / Proteína Tirosina Fosfatasa no Receptora Tipo 1 País/Región como asunto: Asia Idioma: En Revista: Chin J Nat Med Año: 2019 Tipo del documento: Article País de afiliación: China