Breast-conserving surgery vs. total mastectomy in patients with triple negative breast cancer in early stages: A propensity score analysis.
Breast Dis
; 39(1): 29-35, 2020.
Article
en En
| MEDLINE
| ID: mdl-31903977
ABSTRACT
BACKGROUND:
Breast-conserving surgery (BCS) as an alternative to total mastectomy (TM) in patients with early-stage triple-negative breast cancer (TNBC) is not widely spread.OBJECTIVE:
We aimed to compare the overall survival (OS) and disease-free survival (DFS) between both surgical approaches in early-stage TNBC patients at 10 years.METHODS:
We conducted a retrospective cohort study in TNBC female patients with stage I-IIa, treated at a single-center during the period of 2000-2014. We estimated and compared the survival rates with the Kaplan Meier and Long-rank test. Propensity scores were calculated with the generalized boosted regression model and were used in the multivariate Cox regression analysis with the covariate adjustment method.RESULTS:
We included 288 patients, 111 in the BCS vs. 177 in the TM group. The median follow-up was 102 months. Moreover, the patients in the BCS group had superior OS (85% vs. 81%, p = 0.56) and DFS (83% vs. 80%, p = 0.42) at 10 years. In the multivariate Cox analysis, BCS decreased the mortality risk (HR 0.79, 95% CI 0.37-1.67, p = 0.538), and the locoregional or distant recurrence risk (HR 0.67, 95% CI 0.32-1.41, p = 0.294), albeit with no statistical significance.CONCLUSION:
BCS is a safe alternative to TM in Latin-American patients with early-stage TNBC.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Mastectomía Segmentaria
/
Mastectomía Simple
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Neoplasias de la Mama Triple Negativas
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
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Aged
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Female
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Humans
/
Middle aged
Idioma:
En
Revista:
Breast Dis
Asunto de la revista:
GINECOLOGIA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Perú