Through Reducing ROS Production, IL-10 Suppresses Caspase-1-Dependent IL-1ß Maturation, thereby Preventing Chronic Neuroinflammation and Neurodegeneration.

Gao, Yun; Tu, Dezhen; Yang, Ru; Chu, Chun-Hsien; Hong, Jau-Shyong; Gao, Hui-Ming

Gao, Yun; Tu, Dezhen; Yang, Ru; Chu, Chun-Hsien; Hong, Jau-Shyong; Gao, Hui-Ming.

Afiliación

Gao Y; MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Institute for Brain Sciences, Nanjing University, Nanjing 210061, China.
Tu D; Laboratory of Neurobiology, Division of Intramural Research, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, NC 27709, USA.
Yang R; MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Institute for Brain Sciences, Nanjing University, Nanjing 210061, China.
Chu CH; Laboratory of Neurobiology, Division of Intramural Research, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, NC 27709, USA.
Hong JS; MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Institute for Brain Sciences, Nanjing University, Nanjing 210061, China.
Gao HM; Laboratory of Neurobiology, Division of Intramural Research, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, NC 27709, USA.

Int J Mol Sci ; 21(2)2020 Jan 11.

Article en En | MEDLINE | ID: mdl-31940754

Asunto(s)

Caspasa 1/metabolismo; Neuronas Dopaminérgicas/metabolismo; Interleucina-10/metabolismo; Interleucina-1beta/metabolismo; Especies Reactivas de Oxígeno/metabolismo; Animales; Células Cultivadas; Neuronas Dopaminérgicas/efectos de los fármacos; Femenino; Interleucina-10/genética; Lipopolisacáridos/toxicidad; Masculino; Ratones; Ratones Endogámicos C57BL; Microglía/efectos de los fármacos; Microglía/metabolismo; NADPH Oxidasa 2/metabolismo; Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo; Sustancia Negra/citología; Sustancia Negra/metabolismo

Palabras clave

IL-10; IL-1ß; NLRP3 inflammasome; Parkinson's disease; ROS; neuroinflammation

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Interleucina-10 / Especies Reactivas de Oxígeno / Caspasa 1 / Interleucina-1beta / Neuronas Dopaminérgicas Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2020 Tipo del documento: Article País de afiliación: China

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