Assessment of Similarity in Antipsychotic Exposure-Response Relationships in Clinical Trials Between Adults and Adolescents With Acute Exacerbation of Schizophrenia.

Kalaria, Shamir N; Farchione, Tiffany R; Mathis, Mitchell V; Gopalakrishnan, Mathangi; Younis, Islam; Uppoor, Ramana; Mehta, Mehul; Wang, Yaning; Zhu, Hao

Kalaria, Shamir N; Farchione, Tiffany R; Mathis, Mitchell V; Gopalakrishnan, Mathangi; Younis, Islam; Uppoor, Ramana; Mehta, Mehul; Wang, Yaning; Zhu, Hao.

Afiliación

Kalaria SN; Center for Translational Medicine, University of Maryland School of Pharmacy, Baltimore, Maryland, USA.
Farchione TR; Division of Psychiatry Products, Office of New Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, White Oak, Maryland, USA.
Mathis MV; Division of Psychiatry Products, Office of New Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, White Oak, Maryland, USA.
Gopalakrishnan M; Center for Translational Medicine, University of Maryland School of Pharmacy, Baltimore, Maryland, USA.
Younis I; Division of Psychiatry Products, Office of New Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, White Oak, Maryland, USA.
Uppoor R; Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, US Food and Drug Administration, White Oak, Maryland, USA.
Mehta M; Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, US Food and Drug Administration, White Oak, Maryland, USA.
Wang Y; Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, US Food and Drug Administration, White Oak, Maryland, USA.
Zhu H; Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, US Food and Drug Administration, White Oak, Maryland, USA.

J Clin Pharmacol ; 60(7): 848-859, 2020 07.

Article en En | MEDLINE | ID: mdl-31994186

Asunto(s)

Antipsicóticos/farmacocinética; Antipsicóticos/uso terapéutico; Ensayos Clínicos como Asunto; Esquizofrenia/tratamiento farmacológico; Adolescente; Adulto; Anciano; Niño; Simulación por Computador; Bases de Datos Factuales; Relación Dosis-Respuesta a Droga; Aprobación de Drogas; Femenino; Humanos; Masculino; Persona de Mediana Edad; Modelos Biológicos; Efecto Placebo; Escalas de Valoración Psiquiátrica; Resultado del Tratamiento; Estados Unidos; United States Food and Drug Administration; Adulto Joven

Palabras clave

drug efficacy; early-onset schizophrenia; exposure-response; positive and negative symptom scale; second-generation antipsychotics

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Esquizofrenia / Antipsicóticos / Ensayos Clínicos como Asunto Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: J Clin Pharmacol Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google