Virus-Inspired Deformable Mesoporous Nanocomposites for High Efficiency Drug Delivery.
Small
; 16(7): e1906028, 2020 02.
Article
en En
| MEDLINE
| ID: mdl-31994359
ABSTRACT
Mesoporous nanoparticles as a versatile platform for cancer theranostics have been widely used, but their cellular delivery efficiency is still far from satisfactory. Although deformability is emerging as an important parameter influencing cellular uptake enhancement, the facile synthesis of deformable mesoporous nanocomposite with adjustable mechanical property is challenging but meaningful for a deeper understanding of cellular uptake mechanisms and significantly improving cancer therapy. In this work, yolk-shell structured eccentric mesoporous organosilica (YEMO) nanocomposites with adjustable mechanical property are successfully prepared by an organosilane-assisted anisotropic self-assembly approach. The feasibility to precisely control the mechanical property of the YEMO by manipulating the structural parameters, the crosslinking degree of mesoporous framework, and the rotation rate of the reaction is demonstrated. The study of the fabrication mechanism and mechanical properties of YEMO are discussed in detail. The Young's modulus (EY ) of YEMO can be adjusted from 2.4 to 65 MPa. Thereby, the continuous control of the cellular uptake from ≈15% to ≈80% under the same incubation time is achieved. To further prove the higher efficiency drug delivery of YEMO with soft characteristics, the higher toxicity of the "soft" YEMO loaded with the anticancer drug doxorubicin compared to the "stiff" one is demonstrated.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Preparaciones Farmacéuticas
/
Sistemas de Liberación de Medicamentos
/
Nanocompuestos
Idioma:
En
Revista:
Small
Asunto de la revista:
ENGENHARIA BIOMEDICA
Año:
2020
Tipo del documento:
Article
País de afiliación:
China