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Synthesis of novel 9R/S-acyloxy derivatives of cinchonidine and cinchonine as insecticidal agents.
Che, Zhi-Ping; Yang, Jin-Ming; Zhang, Song; Sun, Di; Tian, Yue-E; Liu, Sheng-Ming; Lin, Xiao-Min; Jiang, Jia; Chen, Gen-Qiang.
Afiliación
  • Che ZP; Laboratory of Pesticidal Design & Synthesis, Department of Plant Protection, College of Forestry, Henan University of Science and Technology, Luoyang 471023, China.
  • Yang JM; Laboratory of Pesticidal Design & Synthesis, Department of Plant Protection, College of Forestry, Henan University of Science and Technology, Luoyang 471023, China.
  • Zhang S; Laboratory of Pesticidal Design & Synthesis, Department of Plant Protection, College of Forestry, Henan University of Science and Technology, Luoyang 471023, China.
  • Sun D; Laboratory of Pesticidal Design & Synthesis, Department of Plant Protection, College of Forestry, Henan University of Science and Technology, Luoyang 471023, China.
  • Tian YE; Laboratory of Pesticidal Design & Synthesis, Department of Plant Protection, College of Forestry, Henan University of Science and Technology, Luoyang 471023, China.
  • Liu SM; Laboratory of Pesticidal Design & Synthesis, Department of Plant Protection, College of Forestry, Henan University of Science and Technology, Luoyang 471023, China.
  • Lin XM; Laboratory of Pesticidal Design & Synthesis, Department of Plant Protection, College of Forestry, Henan University of Science and Technology, Luoyang 471023, China.
  • Jiang J; Laboratory of Pesticidal Design & Synthesis, Department of Plant Protection, College of Forestry, Henan University of Science and Technology, Luoyang 471023, China.
  • Chen GQ; Laboratory of Pesticidal Design & Synthesis, Department of Plant Protection, College of Forestry, Henan University of Science and Technology, Luoyang 471023, China.
J Asian Nat Prod Res ; 23(2): 163-175, 2021 Feb.
Article en En | MEDLINE | ID: mdl-32091234
ABSTRACT
Endeavor to discover biorational natural products-based insecticides, two series (27) of novel 9R/S-acyloxy derivatives of cinchonidine and cinchonine were prepared and assessed for their insecticidal activity against Mythimna separata in vivo by the leaf-dipping method at 1 mg/mL. Among all the compounds, especially derivatives 6l and 6o exhibited the best insecticidal activity with final mortality rates of 75.0% and 71.4%, respectively. Overall, a free 9-hydroxyl group is not a prerequisite for insecticidal activity and C9-substitution is well tolerated; the configuration of C8/9 position is important for insecticidal activity, and 9S-configuration is optimal; 6'-OCH3 moiety is not necessary, removal of it is also acceptable. [Formula see text].
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Insecticidas Límite: Animals Idioma: En Revista: J Asian Nat Prod Res Asunto de la revista: BOTANICA / QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: China
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Insecticidas Límite: Animals Idioma: En Revista: J Asian Nat Prod Res Asunto de la revista: BOTANICA / QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: China