Smallest Maximum Intramolecular Distance: A Novel Method to Mitigate Pregnane Xenobiotic Receptor Activation.

Bower, Michael J; Aronov, Alex M; Cleveland, Thomas; Hariparsad, Niresh; McGaughey, Georgia B; McMasters, Daniel R; Zhang, Xiaodan; Goldman, Brian

Bower, Michael J; Aronov, Alex M; Cleveland, Thomas; Hariparsad, Niresh; McGaughey, Georgia B; McMasters, Daniel R; Zhang, Xiaodan; Goldman, Brian.

Afiliación

Bower MJ; Vertex Pharmaceuticals, 50 Northern Avenue, Boston, Massachusetts 02210, United States.
Aronov AM; Vertex Pharmaceuticals, 50 Northern Avenue, Boston, Massachusetts 02210, United States.
Cleveland T; Vertex Pharmaceuticals, 50 Northern Avenue, Boston, Massachusetts 02210, United States.
Hariparsad N; Vertex Pharmaceuticals, 50 Northern Avenue, Boston, Massachusetts 02210, United States.
McGaughey GB; Vertex Pharmaceuticals, 50 Northern Avenue, Boston, Massachusetts 02210, United States.
McMasters DR; Vertex Pharmaceuticals, 50 Northern Avenue, Boston, Massachusetts 02210, United States.
Zhang X; Vertex Pharmaceuticals, 50 Northern Avenue, Boston, Massachusetts 02210, United States.
Goldman B; Vertex Pharmaceuticals, 50 Northern Avenue, Boston, Massachusetts 02210, United States.

J Chem Inf Model ; 60(4): 2091-2099, 2020 04 27.

Article en En | MEDLINE | ID: mdl-32131596

Asunto(s)

Receptores de Esteroides; Citocromo P-450 CYP3A; Interacciones Farmacológicas; Receptor X de Pregnano; Pregnanos; Xenobióticos/toxicidad

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Receptores de Esteroides Idioma: En Revista: J Chem Inf Model Asunto de la revista: INFORMATICA MEDICA / QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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