High density of unrepaired genomic ribonucleotides leads to Topoisomerase 1-mediated severe growth defects in absence of ribonucleotide reductase.

Cerritelli, Susana M; Iranzo, Jaime; Sharma, Sushma; Chabes, Andrei; Crouch, Robert J; Tollervey, David; El Hage, Aziz

Cerritelli, Susana M; Iranzo, Jaime; Sharma, Sushma; Chabes, Andrei; Crouch, Robert J; Tollervey, David; El Hage, Aziz.

Afiliación

Cerritelli SM; SFR, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Iranzo J; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.
Sharma S; Department of Medical Biochemistry and Biophysics, Umeå University, Umeå SE-901 87, Sweden.
Chabes A; Department of Medical Biochemistry and Biophysics, Umeå University, Umeå SE-901 87, Sweden.
Crouch RJ; SFR, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Tollervey D; The Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.
El Hage A; The Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.

Nucleic Acids Res ; 48(8): 4274-4297, 2020 05 07.

Article en En | MEDLINE | ID: mdl-32187369

Asunto(s)

ADN-Topoisomerasas de Tipo I/metabolismo; Ribonucleótido Reductasas/genética; Ribonucleótidos/metabolismo; Proteínas de Saccharomyces cerevisiae/genética; Proteínas de Saccharomyces cerevisiae/metabolismo; Daño del ADN; Desoxirribonucleótidos/metabolismo; Genoma Fúngico; Inestabilidad Genómica; Mutación; Ribonucleasa H/genética; Ribonucleasas/genética; Puntos de Control de la Fase S del Ciclo Celular; Saccharomyces cerevisiae/genética; Saccharomyces cerevisiae/crecimiento & desarrollo; Saccharomyces cerevisiae/metabolismo; Eliminación de Secuencia

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ribonucleótido Reductasas / Ribonucleótidos / ADN-Topoisomerasas de Tipo I / Proteínas de Saccharomyces cerevisiae Idioma: En Revista: Nucleic Acids Res Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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