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Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2.
Mares, Alina; Miah, Afjal H; Smith, Ian E D; Rackham, Mark; Thawani, Aditya R; Cryan, Jenni; Haile, Pamela A; Votta, Bartholomew J; Beal, Allison M; Capriotti, Carol; Reilly, Michael A; Fisher, Don T; Zinn, Nico; Bantscheff, Marcus; MacDonald, Thomas T; Vossenkamper, Anna; Dace, Phoebe; Churcher, Ian; Benowitz, Andrew B; Watt, Gillian; Denyer, Jane; Scott-Stevens, Paul; Harling, John D.
Afiliación
  • Mares A; Medicine Design, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK.
  • Miah AH; Medicine Design, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK.
  • Smith IED; Medicine Design, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK.
  • Rackham M; Medicine Design, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK.
  • Thawani AR; Medicine Design, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK.
  • Cryan J; Medicine Design, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK.
  • Haile PA; Innate Immunity Research Unit, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA, 19426, USA.
  • Votta BJ; Innate Immunity Research Unit, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA, 19426, USA.
  • Beal AM; Innate Immunity Research Unit, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA, 19426, USA.
  • Capriotti C; Innate Immunity Research Unit, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA, 19426, USA.
  • Reilly MA; Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA, 19426, USA.
  • Fisher DT; Drug Design and Selection, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA, 19426, USA.
  • Zinn N; Cellzome, a GSK company, Meyerhofstrasse 1, 69117, Heidelberg, Germany.
  • Bantscheff M; Cellzome, a GSK company, Meyerhofstrasse 1, 69117, Heidelberg, Germany.
  • MacDonald TT; Centre for Immunobiology, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, E1 2AT, London, UK.
  • Vossenkamper A; Centre for Immunobiology, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, E1 2AT, London, UK.
  • Dace P; Medicine Design, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK.
  • Churcher I; Medicine Design, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK.
  • Benowitz AB; Medicine Design, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK.
  • Watt G; Medicine Design, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK.
  • Denyer J; Medicine Design, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK.
  • Scott-Stevens P; Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK.
  • Harling JD; Medicine Design, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK. john.d.harling@gsk.com.
Commun Biol ; 3(1): 140, 2020 03 20.
Article en En | MEDLINE | ID: mdl-32198438
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Leucocitos Mononucleares / Diseño de Fármacos / Ubiquitina-Proteína Ligasas / Complejo de la Endopetidasa Proteasomal / Proteína Serina-Treonina Quinasa 2 de Interacción con Receptor / Inflamación / Antiinflamatorios Límite: Animals / Female / Humans / Male Idioma: En Revista: Commun Biol Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Leucocitos Mononucleares / Diseño de Fármacos / Ubiquitina-Proteína Ligasas / Complejo de la Endopetidasa Proteasomal / Proteína Serina-Treonina Quinasa 2 de Interacción con Receptor / Inflamación / Antiinflamatorios Límite: Animals / Female / Humans / Male Idioma: En Revista: Commun Biol Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido