All-trans retinoic acid reduces cancer stem cell-like cell-mediated resistance to gefitinib in NSCLC adenocarcinoma cells.

Yao, Wenxiu; Wang, Liyang; Huang, Huan; Li, Xin; Wang, Pinjia; Mi, Kun; Cheng, Jia; Liu, Huifen; Gu, Cuirong; Huang, Lingxiao; Huang, Jianming

Yao, Wenxiu; Wang, Liyang; Huang, Huan; Li, Xin; Wang, Pinjia; Mi, Kun; Cheng, Jia; Liu, Huifen; Gu, Cuirong; Huang, Lingxiao; Huang, Jianming.

Afiliación

Yao W; Department of Medical oncology, Sichuan Cancer Hospital, Medical School of University of Electronic Science and Technology of China, Chengdu, 610041, People's Republic of China.
Wang L; Department of Medical oncology, Sichuan Cancer Hospital, Medical School of University of Electronic Science and Technology of China, Chengdu, 610041, People's Republic of China.
Huang H; Department of Medical oncology, Wuming Hospital Affiliated to Guangxi Medical University, Nanning, 530000, China.
Li X; Department of Medical oncology, Sichuan Cancer Hospital, Medical School of University of Electronic Science and Technology of China, Chengdu, 610041, People's Republic of China.
Wang P; Department of Medical oncology, Sichuan Cancer Hospital, Medical School of University of Electronic Science and Technology of China, Chengdu, 610041, People's Republic of China.
Mi K; Department of Biochemistry & Molecular Biology, Sichuan Cancer Insititute, No.55, Section 4, South Renmin Road, Chengdu, 610041, People's Republic of China.
Cheng J; Department of Biochemistry & Molecular Biology, Sichuan Cancer Insititute, No.55, Section 4, South Renmin Road, Chengdu, 610041, People's Republic of China.
Liu H; Department of Biochemistry & Molecular Biology, Sichuan Cancer Insititute, No.55, Section 4, South Renmin Road, Chengdu, 610041, People's Republic of China.
Gu C; Department of Biochemistry & Molecular Biology, Sichuan Cancer Insititute, No.55, Section 4, South Renmin Road, Chengdu, 610041, People's Republic of China.
Huang L; Department of Biochemistry & Molecular Biology, Sichuan Cancer Insititute, No.55, Section 4, South Renmin Road, Chengdu, 610041, People's Republic of China.
Huang J; Department of Biochemistry & Molecular Biology, Sichuan Cancer Insititute, No.55, Section 4, South Renmin Road, Chengdu, 610041, People's Republic of China. hjianming@yahoo.com.

BMC Cancer ; 20(1): 315, 2020 Apr 15.

Article en En | MEDLINE | ID: mdl-32293355

Asunto(s)

Carcinoma de Pulmón de Células no Pequeñas/genética; Resistencia a Antineoplásicos/efectos de los fármacos; Gefitinib/farmacología; Neoplasias Pulmonares/genética; Células Madre Neoplásicas/efectos de los fármacos; Tretinoina/farmacología; Células A549; Familia de Aldehído Deshidrogenasa 1/genética; Familia de Aldehído Deshidrogenasa 1/metabolismo; Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico; Carcinoma de Pulmón de Células no Pequeñas/metabolismo; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Supervivencia Celular/efectos de los fármacos; Sinergismo Farmacológico; Femenino; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Humanos; Receptores de Hialuranos/genética; Receptores de Hialuranos/metabolismo; Concentración 50 Inhibidora; Neoplasias Pulmonares/tratamiento farmacológico; Neoplasias Pulmonares/metabolismo; Células Madre Neoplásicas/metabolismo; Retinal-Deshidrogenasa/genética; Retinal-Deshidrogenasa/metabolismo; Regulación hacia Arriba/efectos de los fármacos

Palabras clave

ALDH1A1; All-trans retinoic acid; CD44; EGFR tyrosine kinase inhibitors; Non-small cell lung adenocarcinoma

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tretinoina / Células Madre Neoplásicas / Carcinoma de Pulmón de Células no Pequeñas / Resistencia a Antineoplásicos / Gefitinib / Neoplasias Pulmonares Límite: Female / Humans Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2020 Tipo del documento: Article

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