Blockade of Dopamine D2 Receptors as a Novel Approach to Stimulation of Notch1<sup>+</sup> Endothelial Progenitor Cells and Angiogenesis in C57BL/6 Mice with Pulmonary Emphysema Induced by Proteases and Deficiency of &#945;1-Antitrypsin.

Skurikhin, E G; Krupin, V A; Pershina, O V; Pan, E S; Pakhomova, A V; Sandrikina, L A; Ermakova, N N; Vaizova, O E; Zhukova, M A; Dygai, A M

Blockade of Dopamine D2 Receptors as a Novel Approach to Stimulation of Notch1⁺ Endothelial Progenitor Cells and Angiogenesis in C57BL/6 Mice with Pulmonary Emphysema Induced by Proteases and Deficiency of α1-Antitrypsin.

Skurikhin, E G; Krupin, V A; Pershina, O V; Pan, E S; Pakhomova, A V; Sandrikina, L A; Ermakova, N N; Vaizova, O E; Zhukova, M A; Dygai, A M.

Afiliación

Skurikhin EG; Laboratory of Regenerative Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Moscow, Russia. eskurikhin@inbox.ru.
Krupin VA; Laboratory of Regenerative Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Moscow, Russia.
Pershina OV; Laboratory of Regenerative Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Moscow, Russia.
Pan ES; Laboratory of Regenerative Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Moscow, Russia.
Pakhomova AV; Laboratory of Regenerative Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Moscow, Russia.
Sandrikina LA; Laboratory of Regenerative Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Moscow, Russia.
Ermakova NN; Laboratory of Regenerative Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Moscow, Russia.
Vaizova OE; Department of Pharmacology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
Zhukova MA; Department of Pharmacology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
Dygai AM; Laboratory of Regenerative Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Moscow, Russia.

Bull Exp Biol Med ; 168(6): 718-723, 2020 Apr.

Article en En | MEDLINE | ID: mdl-32328949

Asunto(s)

Antagonistas de Dopamina/farmacología; Células Progenitoras Endoteliales/efectos de los fármacos; Enfisema Pulmonar/tratamiento farmacológico; Receptor Notch1/genética; Receptores de Dopamina D2/genética; Espiperona/farmacología; Deficiencia de alfa 1-Antitripsina/tratamiento farmacológico; Animales; Células Progenitoras Endoteliales/metabolismo; Células Progenitoras Endoteliales/patología; Femenino; Galactosamina/administración & dosificación; Regulación de la Expresión Génica; Hepatocitos/efectos de los fármacos; Hepatocitos/metabolismo; Hepatocitos/patología; Hígado/efectos de los fármacos; Hígado/metabolismo; Hígado/patología; Pulmón/efectos de los fármacos; Pulmón/metabolismo; Pulmón/patología; Ratones; Ratones Endogámicos C57BL; Neovascularización Fisiológica/efectos de los fármacos; Elastasa Pancreática/administración & dosificación; Fosforilación/efectos de los fármacos; Molécula-1 de Adhesión Celular Endotelial de Plaqueta/genética; Molécula-1 de Adhesión Celular Endotelial de Plaqueta/metabolismo; Enfisema Pulmonar/inducido químicamente; Enfisema Pulmonar/genética; Enfisema Pulmonar/metabolismo; Receptor Notch1/agonistas; Receptor Notch1/metabolismo; Receptores de Dopamina D2/metabolismo; Regeneración/efectos de los fármacos; Receptor 2 de Factores de Crecimiento Endotelial Vascular/genética; Receptor 2 de Factores de Crecimiento Endotelial Vascular/metabolismo; alfa 1-Antitripsina/genética; alfa 1-Antitripsina/metabolismo; Deficiencia de alfa 1-Antitripsina/enzimología; Deficiencia de alfa 1-Antitripsina/genética; Deficiencia de alfa 1-Antitripsina/patología

Palabras clave

Notch1 signaling; endothelial progenitor cells; pulmonary emphysema; spiperone; α1-antitrypsin

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfisema Pulmonar / Espiperona / Receptores de Dopamina D2 / Antagonistas de Dopamina / Deficiencia de alfa 1-Antitripsina / Receptor Notch1 / Células Progenitoras Endoteliales Tipo de estudio: Prognostic_studies Idioma: En Revista: Bull Exp Biol Med Año: 2020 Tipo del documento: Article País de afiliación: Rusia

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