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Maternal and paternal effects on offspring internalizing problems: Results from genetic and family-based analyses.
Jami, Eshim S; Eilertsen, Espen Moen; Hammerschlag, Anke R; Qiao, Zhen; Evans, David M; Ystrøm, Eivind; Bartels, Meike; Middeldorp, Christel M.
Afiliación
  • Jami ES; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  • Eilertsen EM; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
  • Hammerschlag AR; Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.
  • Qiao Z; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  • Evans DM; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
  • Ystrøm E; Child Health Research Centre, University of Queensland, Brisbane, Australia.
  • Bartels M; The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, Australia.
  • Middeldorp CM; The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, Australia.
Am J Med Genet B Neuropsychiatr Genet ; 183(5): 258-267, 2020 07.
Article en En | MEDLINE | ID: mdl-32356930
ABSTRACT
It is unclear to what extent parental influences on the development of internalizing problems in offspring are explained by indirect genetic effects, reflected in the environment provided by the parent, in addition to the genes transmitted from parent to child. In this study, these effects were investigated using two innovative methods in a large birth cohort. Using maternal-effects genome complex trait analysis (M-GCTA), the effects of offspring genotype, maternal or paternal genotypes, and their covariance on offspring internalizing problems were estimated in 3,801 mother-father-child genotyped trios. Next, estimated genetic correlations within pedigree data, including 10,688 children, were used to estimate additive genetic effects, maternal and paternal genetic effects, and a shared family effect using linear mixed effects modeling. There were no significant maternal or paternal genetic effects on offspring anxiety or depressive symptoms at age 8, beyond the effects transmitted via the genetic pathway between parents and children. However, indirect maternal genetic effects explained a small, but nonsignificant, proportion of variance in childhood depressive symptoms in both the M-GCTA (~4%) and pedigree (~8%) analyses. Our results suggest that parental effects on offspring internalizing problems are predominantly due to transmitted genetic variants, rather than the indirect effect of parental genes via the environment.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trastornos de Ansiedad / Relaciones Padres-Hijo / Herencia Materna / Herencia Paterna Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Am J Med Genet B Neuropsychiatr Genet Asunto de la revista: GENETICA MEDICA / NEUROLOGIA / PSIQUIATRIA Año: 2020 Tipo del documento: Article País de afiliación: Países Bajos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trastornos de Ansiedad / Relaciones Padres-Hijo / Herencia Materna / Herencia Paterna Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Am J Med Genet B Neuropsychiatr Genet Asunto de la revista: GENETICA MEDICA / NEUROLOGIA / PSIQUIATRIA Año: 2020 Tipo del documento: Article País de afiliación: Países Bajos