MCT2 overexpression rescues metabolic vulnerability and protects retinal ganglion cells in two models of glaucoma.

Harun-Or-Rashid, Mohammad; Pappenhagen, Nathaniel; Zubricky, Ryan; Coughlin, Lucy; Jassim, Assraa Hassan; Inman, Denise M

Harun-Or-Rashid, Mohammad; Pappenhagen, Nathaniel; Zubricky, Ryan; Coughlin, Lucy; Jassim, Assraa Hassan; Inman, Denise M.

Afiliación

Harun-Or-Rashid M; Case Western Reserve University, Cleveland, OH, United States of America.
Pappenhagen N; Department of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH, United States of America; School of Biomedical Sciences, Kent State University, Kent, OH, United States of America.
Zubricky R; Department of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH, United States of America.
Coughlin L; Department of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH, United States of America; School of Biomedical Sciences, Kent State University, Kent, OH, United States of America.
Jassim AH; Department of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH, United States of America.
Inman DM; Department of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH, United States of America. Electronic address: denise.inman@unthsc.edu.

Neurobiol Dis ; 141: 104944, 2020 07.

Article en En | MEDLINE | ID: mdl-32422282

Asunto(s)

Glaucoma/metabolismo; Transportadores de Ácidos Monocarboxílicos/metabolismo; Células Ganglionares de la Retina/metabolismo; Animales; Modelos Animales de Enfermedad; Potenciales Evocados Visuales; Femenino; Glaucoma/patología; Glaucoma/fisiopatología; Masculino; Ratones Transgénicos; Microglía/metabolismo; Mitocondrias/metabolismo; Transportadores de Ácidos Monocarboxílicos/genética; Hipertensión Ocular/metabolismo; Nervio Óptico/metabolismo; Células Ganglionares de la Retina/patología

Palabras clave

Glaucoma; Metabolism; Monocarboxylate transporter; Ocular hypertension; Retinal ganglion cell

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Células Ganglionares de la Retina / Glaucoma / Transportadores de Ácidos Monocarboxílicos Límite: Animals Idioma: En Revista: Neurobiol Dis Asunto de la revista: NEUROLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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