Bradykinin-mediated edema formation is blocked by levorotatory but not dextrorotatory terbutaline.
Microcirc Endothelium Lymphatics
; 4(5): 377-97, 1988 Oct.
Article
en En
| MEDLINE
| ID: mdl-3244331
ABSTRACT
The ability of the purified stereoisomers of the beta 2-receptor agonist terbutaline to block bradykinin-mediated increases in lymph flow and protein concentration was assessed in the canine forelimb perfused at constant arterial flow. Intra-arterial infusion of bradykinin (2 micrograms/min, n = 8) decreased forelimb arterial pressures but did not affect skin small vein pressure or systemic pressure. Lymph flow, protein concentration and protein transport were significantly increased. Intra-arterial infusion of 1-terbutaline (1 microgram/min, n = 9) decreased forelimb arterial pressures and systemic pressure but did not affect lymph parameters. Subsequent infusion of bradykinin during the continued infusion of 1-terbutaline failed to alter forelimb lymph parameters. Intra-arterial infusion of d-terbutaline (1 microgram/min, n = 11) did not alter vascular pressures or lymph parameters. Subsequent infusion of bradykinin during the continued infusion of d-terbutaline decreased forelimb arterial pressures and significantly increased lymph flow, protein concentration and protein transport. Intra-arterial infusion of a high dose (100 micrograms/min, n = 9) of d-terbutaline significantly decreased forelimb arterial pressure but was likewise ineffective in blocking the increases in lymph parameters produced by subsequent bradykinin infusion. These data indicate that the beta 2-receptor agonistic and anti-permeability actions of terbutaline are found solely in the levorotatory enantiomer.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Terbutalina
/
Bradiquinina
/
Edema
Límite:
Animals
Idioma:
En
Revista:
Microcirc Endothelium Lymphatics
Asunto de la revista:
ANGIOLOGIA
Año:
1988
Tipo del documento:
Article