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The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions.
Littlejohns, Thomas J; Holliday, Jo; Gibson, Lorna M; Garratt, Steve; Oesingmann, Niels; Alfaro-Almagro, Fidel; Bell, Jimmy D; Boultwood, Chris; Collins, Rory; Conroy, Megan C; Crabtree, Nicola; Doherty, Nicola; Frangi, Alejandro F; Harvey, Nicholas C; Leeson, Paul; Miller, Karla L; Neubauer, Stefan; Petersen, Steffen E; Sellors, Jonathan; Sheard, Simon; Smith, Stephen M; Sudlow, Cathie L M; Matthews, Paul M; Allen, Naomi E.
Afiliación
  • Littlejohns TJ; Nuffield Department of Population Health, University of Oxford, Oxford, UK. thomas.littlejohns@ndph.ox.ac.uk.
  • Holliday J; Nuffield Department of Population Health, University of Oxford, Oxford, UK.
  • Gibson LM; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
  • Garratt S; Department of Clinical Radiology, New Royal Infirmary of Edinburgh, Edinburgh, UK.
  • Oesingmann N; UK Biobank Coordinating Centre, Stockport, UK.
  • Alfaro-Almagro F; UK Biobank Coordinating Centre, Stockport, UK.
  • Bell JD; Centre for Functional MRI of the Brain, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK.
  • Boultwood C; Research Centre for Optimal Health, University of Westminster, London, UK.
  • Collins R; UK Biobank Coordinating Centre, Stockport, UK.
  • Conroy MC; Nuffield Department of Population Health, University of Oxford, Oxford, UK.
  • Crabtree N; Nuffield Department of Population Health, University of Oxford, Oxford, UK.
  • Doherty N; Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.
  • Frangi AF; UK Biobank Coordinating Centre, Stockport, UK.
  • Harvey NC; Department of Cardiovascular Sciences and Electrical Engineering, KU Leuven, Leuven, Belgium.
  • Leeson P; CISTIB Centre for Computational Imaging and Simulation Technologies in Biomedicine, Schools of Computing and Medicine, University of Leeds, Leeds, UK.
  • Miller KL; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
  • Neubauer S; Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
  • Petersen SE; Centre for Functional MRI of the Brain, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK.
  • Sellors J; Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
  • Sheard S; William Harvey Research Institute, Queen Mary University of Medicine, London, UK.
  • Smith SM; Nuffield Department of Population Health, University of Oxford, Oxford, UK.
  • Sudlow CLM; UK Biobank Coordinating Centre, Stockport, UK.
  • Matthews PM; UK Biobank Coordinating Centre, Stockport, UK.
  • Allen NE; Centre for Functional MRI of the Brain, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK.
Nat Commun ; 11(1): 2624, 2020 05 26.
Article en En | MEDLINE | ID: mdl-32457287
ABSTRACT
UK Biobank is a population-based cohort of half a million participants aged 40-69 years recruited between 2006 and 2010. In 2014, UK Biobank started the world's largest multi-modal imaging study, with the aim of re-inviting 100,000 participants to undergo brain, cardiac and abdominal magnetic resonance imaging, dual-energy X-ray absorptiometry and carotid ultrasound. The combination of large-scale multi-modal imaging with extensive phenotypic and genetic data offers an unprecedented resource for scientists to conduct health-related research. This article provides an in-depth overview of the imaging enhancement, including the data collected, how it is managed and processed, and future directions.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Aumento de la Imagen / Bancos de Muestras Biológicas / Gestión de la Información Tipo de estudio: Diagnostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Aumento de la Imagen / Bancos de Muestras Biológicas / Gestión de la Información Tipo de estudio: Diagnostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido