A 3'UTR modification of the TNF-&#945; mouse gene increases peripheral TNF-&#945; and modulates the Alzheimer-like phenotype in 5XFAD mice.

Kalovyrna, Nikoleta; Apokotou, Olympia; Boulekou, Sotiria; Paouri, Evi; Boutou, Athena; Georgopoulos, Spiros

A 3'UTR modification of the TNF-α mouse gene increases peripheral TNF-α and modulates the Alzheimer-like phenotype in 5XFAD mice.

Kalovyrna, Nikoleta; Apokotou, Olympia; Boulekou, Sotiria; Paouri, Evi; Boutou, Athena; Georgopoulos, Spiros.

Afiliación

Kalovyrna N; Laboratory of Cellular Neurobiology, Center of Basic Research, Biomedical Research Foundation, Academy of Athens, 11527, Athens, Greece.
Apokotou O; Laboratory of Cellular Neurobiology, Center of Basic Research, Biomedical Research Foundation, Academy of Athens, 11527, Athens, Greece.
Boulekou S; Laboratory of Cellular Neurobiology, Center of Basic Research, Biomedical Research Foundation, Academy of Athens, 11527, Athens, Greece.
Paouri E; Laboratory of Cellular Neurobiology, Center of Basic Research, Biomedical Research Foundation, Academy of Athens, 11527, Athens, Greece.
Boutou A; Laboratory of Cellular Neurobiology, Center of Basic Research, Biomedical Research Foundation, Academy of Athens, 11527, Athens, Greece.
Georgopoulos S; Laboratory of Cellular Neurobiology, Center of Basic Research, Biomedical Research Foundation, Academy of Athens, 11527, Athens, Greece. sgeorgopoulos@bioacademy.gr.

Sci Rep ; 10(1): 8670, 2020 05 26.

Article en En | MEDLINE | ID: mdl-32457323

Asunto(s)

Regiones no Traducidas 3'/genética; Enfermedad de Alzheimer/patología; Péptidos beta-Amiloides/metabolismo; Placa Amiloide/patología; Factor de Necrosis Tumoral alfa/genética; Enfermedad de Alzheimer/genética; Animales; Artritis Reumatoide/genética; Encéfalo/patología; Enfermedad de Crohn/genética; Modelos Animales de Enfermedad; Femenino; Técnicas de Sustitución del Gen; Activación de Macrófagos/inmunología; Macrófagos/inmunología; Ratones; Ratones Endogámicos C57BL; Ratones Transgénicos; Microglía/metabolismo; Factor de Necrosis Tumoral alfa/metabolismo

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Péptidos beta-Amiloides / Factor de Necrosis Tumoral alfa / Placa Amiloide / Regiones no Traducidas 3' / Enfermedad de Alzheimer Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Sci Rep Año: 2020 Tipo del documento: Article País de afiliación: Grecia

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